Mutation of divergent region 1 alters caffeine and Ca(2+) sensitivity of the skeletal muscle Ca(2+) release channel (ryanodine receptor).
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Central core diseaseMutations to Gly2370, Gly2373 or Gly2375 in malignant hyperthermia domain 2 decrease caffeine and cresol sensitivity of the rabbit skeletal-muscle Ca2+-release channel (ryanodine receptor isoform 1)The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gatingDynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptorInsight towards the identification of cytosolic Ca2+ -binding sites in ryanodine receptors from skeletal and cardiac muscle.Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.Ryanodine receptors: structure, expression, molecular details, and function in calcium release.Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer.Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1).Malignant hyperthermia and excitation-contraction coupling.Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.The structural biology of ryanodine receptors.Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation.Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivationRole of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1).Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites.Functional characterization of mutants in the predicted pore region of the rabbit cardiac muscle Ca(2+) release channel (ryanodine receptor isoform 2).Identification of apocalmodulin and Ca2+-calmodulin regulatory domain in skeletal muscle Ca2+ release channel, ryanodine receptor.Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor).Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1.Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.Lanthanides Report Calcium Sensor in the Vestibule of Ryanodine Receptor.Multiscale modeling of calcium signaling in the cardiac dyad.
P2860
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P2860
Mutation of divergent region 1 alters caffeine and Ca(2+) sensitivity of the skeletal muscle Ca(2+) release channel (ryanodine receptor).
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
Mutation of divergent region 1 ...... channel (ryanodine receptor).
@en
type
label
Mutation of divergent region 1 ...... channel (ryanodine receptor).
@en
prefLabel
Mutation of divergent region 1 ...... channel (ryanodine receptor).
@en
P2093
P2860
P356
P1476
Mutation of divergent region 1 ...... channel (ryanodine receptor).
@en
P2093
P2860
P304
11778-11783
P356
10.1074/JBC.275.16.11778
P407
P577
2000-04-01T00:00:00Z