Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor).
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Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmiasThe role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium.K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association'Ryanopathy': causes and manifestations of RyR2 dysfunction in heart failureStructural Basis for Gating and Activation of RyR1.Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor)RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gatingMg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrationsInsight towards the identification of cytosolic Ca2+ -binding sites in ryanodine receptors from skeletal and cardiac muscle.Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptorsIncreased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).Smooth muscle tissues express a major dominant negative splice variant of the type 3 Ca2+ release channel (ryanodine receptor).Ca2+ activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling.Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensorThe ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmiasLocalization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release.The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine ReceptorA mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain.Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.Ryanodine receptor structure: progress and challenges.Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptorLocalization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor.Calcium-induced calcium release in skeletal muscle.IP(3) receptors: toward understanding their activation.ARVC-related mutations in divergent region 3 alter functional properties of the cardiac ryanodine receptor.Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle.Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivationFrom contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site- and function-specific calcium signals.The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating.Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.
P2860
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P2860
Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor).
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Molecular basis of Ca(2)+ acti ...... channel (ryanodine receptor).
@en
type
label
Molecular basis of Ca(2)+ acti ...... channel (ryanodine receptor).
@en
prefLabel
Molecular basis of Ca(2)+ acti ...... channel (ryanodine receptor).
@en
P2860
P356
P1476
Molecular basis of Ca(2)+ acti ...... channel (ryanodine receptor).
@en
P2860
P356
10.1085/JGP.118.1.33
P577
2001-07-01T00:00:00Z