Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules.
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Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferaseDual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.O-fucosylation is required for ADAMTS13 secretionThe human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamineAntibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivoIdentification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeatsRumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferaseProtein O-fucosyltransferase 1 is an essential component of Notch signaling pathwaysNotch Signaling in Neuroendocrine TumorsHijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic PhenotypesGlycosylated Notch and CancerThe protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in DrosophilaNegative regulation of notch signaling by xyloseCrystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosisFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsXylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesisMolecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notchFringe is a glycosyltransferase that modifies NotchC-mannosylation and O-fucosylation of the thrombospondin type 1 moduleNotch ligands are substrates for protein O-fucosyltransferase-1 and FringeIdentification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeatsCharacterization of a family of Arabidopsis genes related to xyloglucan fucosyltransferase1O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulationRegulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase RumiSegmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceO-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand functionO-fucosylation of DLL3 is required for its function during somitogenesisA POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss.Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets.Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity.Competition between Delta and the Abruptex domain of NotchEffects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes.O-fucose modulates Notch-controlled blood lineage commitment.Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1Role of glycosylation of Notch in developmentRole of glycans and glycosyltransferases in the regulation of Notch signalingPhosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation.Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds.C-mannosylation and o-fucosylation of thrombospondin type 1 repeats.
P2860
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P2860
Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Mammalian Notch1 is modified w ...... al growth factor-like modules.
@en
type
label
Mammalian Notch1 is modified w ...... al growth factor-like modules.
@en
prefLabel
Mammalian Notch1 is modified w ...... al growth factor-like modules.
@en
P2093
P2860
P356
P1476
Mammalian Notch1 is modified w ...... al growth factor-like modules.
@en
P2093
Haltiwanger RS
Moloney DJ
P2860
P304
P356
10.1074/JBC.275.13.9604
P407
P577
2000-03-01T00:00:00Z