Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
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Principles of interleukin (IL)-6-type cytokine signalling and its regulationOncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosisStructural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane ComplexA functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptorFunction and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligandsN-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesNovel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis.Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.The cytokine receptor gp130: faithfully promiscuous.New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis.Molecular interactions within the IL-6/IL-12 cytokine/receptor superfamily.Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation.Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains.Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.The dynamics of signal triggering in a gp130-receptor complex.Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential.Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.Identification of an oncostatin M receptor mutation associated with familial primary cutaneous amyloidosis.Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor.gp130 activation is regulated by D2-D3 interdomain connectivity.
P2860
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P2860
Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Importance of the membrane-pro ...... l transducer glycoprotein 130.
@en
type
label
Importance of the membrane-pro ...... l transducer glycoprotein 130.
@en
prefLabel
Importance of the membrane-pro ...... l transducer glycoprotein 130.
@en
P2093
P1476
Importance of the membrane-pro ...... l transducer glycoprotein 130.
@en
P2093
Heinrich PC
Müller-Newen G
Timmermann A
P304
P356
10.4049/JIMMUNOL.164.1.273
P407
P577
2000-01-01T00:00:00Z