Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation. - Wikidata - awgldk - TriplyDB

Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.

Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.

http://www.wikidata.org/entity/Q40918885

about

Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif Proteomic analysis of the secretome of Leishmania donovani Impact of Leishmania metalloprotease GP63 on macrophage signaling The host-protective effect of arabinosylated lipoarabinomannan against Leishmania donovani infection is associated with restoration of IFN-γ responsiveness Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol Entamoeba histolytica-induced dephosphorylation in host cells.Macrophage and T-cell gene expression in a model of early infection with the protozoan Leishmania chagasi.Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice.Identifying vaccine targets for anti-leishmanial vaccine development Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view.Leishmania interferes with host cell signaling to devise a survival strategy.Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis.Immune regulation during chronic visceral leishmaniasis.Temperature-induced protein secretion by Leishmania mexicana modulates macrophage signalling and function.Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate.Leishmania donovani amastigotes impair gamma interferon-induced STAT1alpha nuclear translocation by blocking the interaction between STAT1alpha and importin-alpha5 Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages.Impact of neutrophil-secreted myeloid related proteins 8 and 14 (MRP 8/14) on leishmaniasis progression.Use of antimony in the treatment of leishmaniasis: current status and future directions.Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection.The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response.Macrophage and Leishmania: an unacceptable coexistence.Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype.CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response.Immune privilege in sites of chronic infection: Leishmania and regulatory T cells.Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.The amastigote forms of Leishmania are experts at exploiting host cell processes to establish infection and persist.Functional paradox in host-pathogen interaction dictates the fate of parasites.Mechanisms of immune evasion in leishmaniasis The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.Leishmania major inhibits IL-12 in macrophages by signalling through CR3 (CD11b/CD18) and down-regulation of ETS-mediated transcription.Secreted virulence factors and immune evasion in visceral leishmaniasis.Leishmania exosomes deliver preemptive strikes to create an environment permissive for early infection.Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis.The genetics of Leishmania virulence.Trypanosoma cruzi parasites fight for control of the JAK-STAT pathway by disarming their host.Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.Evasion of Host Defence by Leishmania donovani: Subversion of Signaling Pathways.

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Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-gamma-triggered JAK2 activation.

http://www.wikidata.org/entity/Q40918885

description

1999 nî lūn-bûn

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1999年學術文章

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1999年學術文章

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1999年學術文章

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name

Leishmania-induced increases i ...... mma-triggered JAK2 activation.

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Leishmania-induced increases i ...... mma-triggered JAK2 activation.

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Leishmania-induced increases i ...... mma-triggered JAK2 activation.

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(SICI)1521-4141(199911)29:11%3C3737::AID-IMMU3737%3E3.0.CO;2-S

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European Journal of Immunology

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Leishmania-induced increases i ...... mma-triggered JAK2 activation.

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P2093

Blanchette J

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Faure R

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Olivier M

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Racette N

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Siminovitch KA

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P2860

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling

Crystal structure of the tyrosine phosphatase SHP-2

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

Lipoarabinomannan of Mycobacterium tuberculosis promotes protein tyrosine dephosphorylation and inhibition of mitogen-activated protein kinase in human mononuclear phagocytes. Role of the Src homology 2 containing tyrosine phosphatase 1

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase

Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1

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3737-3744

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10.1002/(SICI)1521-4141(199911)29:11<3737::AID-IMMU3737>3.0.CO;2-S

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10556830

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