Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
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Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationSalicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigenHyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytesCellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factorsMice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficitPhosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-CellsAmino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationHyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunctionAmino-acid-dependent signal transduction.Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylationImpairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in miceNeutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinaseReassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway.Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of rapamycin.NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.Cell hydration and mTOR-dependent signalling.The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.Exploiting p70 S6 kinase as a target for ovarian cancer.Transcriptional regulation of the stress response by mTOR.Lysosomal recruitment of TSC2 is a universal response to cellular stressTSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.Molecular mechanisms of mTOR regulation by stressLithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner.Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase.Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells.A novel 68-kDa adipocyte protein phosphorylated on tyrosine in response to insulin and osmotic shock.Amino-terminal-derived JNK fragment alters expression and activity of c-Jun, ATF2, and p53 and increases H2O2-induced cell death.Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis.The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.
P2860
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P2860
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
@en
type
label
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
@en
prefLabel
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
@en
P2860
P356
P1476
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
@en
P2093
D J Templeton
L A Parrott
P2860
P304
24731-24736
P356
10.1074/JBC.274.35.24731
P407
P577
1999-08-01T00:00:00Z