Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain.
about
Ovarian cancer, the coagulation pathway, and inflammationSpecificity of coagulation factor signalingTranscriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cellsTissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration.Tissue factor-factor VIIa signaling.Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor.Protease activated receptors: theme and variations.The hemostatic system and angiogenesis in malignancy.Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant miceThe cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia.Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathwaysTissue factor as a novel target for treatment of breast cancerRegulation of tissue factor coagulant activity on cell surfaces.Structure-Function Relationship of the Interaction between Tissue Factor and Factor VIIa.Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae.Tissue factor non-coagulant signaling - molecular mechanisms and biological consequences with a focus on cell migration and apoptosis.Factor VIIa regulates the expression of caspase-3, MMP-9, and CD44 in SW620 colon cancer cells involving PAR2/MAPKs/NF-κB signaling pathways.Tissue factor-Akt signaling triggers microvessel formation.Treatment with anti-factor VIIa in acute pancreatitis in rats: blocking both coagulation and inflammation?Tissue factor enhances protease-activated receptor-2-mediated factor VIIa cell proliferative properties.Coagulation factors VIIa and Xa inhibit apoptosis and anoikis.Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells.VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation.Active site blockade of factor VIIa alters its intracellular distribution.Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline/LPS renal injury in mice.Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide.Role of the tissue factor pathway in synovial inflammation.Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain.Antithrombotic agents in the treatment of severe sepsis.Identification of the coagulation factor VIIa integrin binding site required for pro-angiogenic PAR2 signaling.Blockade of tissue factor: treatment for organ injury in established sepsis.Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.
P2860
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P2860
Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Factor VIIa-induced p44/42 mit ...... sue factor cytoplasmic domain.
@en
type
label
Factor VIIa-induced p44/42 mit ...... sue factor cytoplasmic domain.
@en
prefLabel
Factor VIIa-induced p44/42 mit ...... sue factor cytoplasmic domain.
@en
P2093
P2860
P356
P1476
Factor VIIa-induced p44/42 mit ...... sue factor cytoplasmic domain.
@en
P2093
P2860
P304
21349-21354
P356
10.1074/JBC.274.30.21349
P407
P577
1999-07-01T00:00:00Z