Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation.
about
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifsTyrosine phosphorylation of the Tio oncoprotein is essential for transformation of primary human T cellsSpecific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatasePartial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry.Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri TipHIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.Downregulation of p56(lck) tyrosine kinase activity in T cells of squirrel monkeys (Saimiri sciureus) correlates with the nontransforming and apathogenic properties of herpesvirus saimiri in its natural hostLck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.Viral modulation of T-cell receptor signalingMolecular mechanisms of the effect of herpesvirus saimiri protein StpC on the signaling pathway leading to NF-kappaB activation.Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein tip.Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein.Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip.T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.Herpesvirus saimiri replaces ZAP-70 for CD3- and CD2-mediated T cell activation.Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4(+) and CD8(+) T lymphocytes is ATM-independent.
P2860
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P2860
Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Activation of the lck tyrosine ...... tory tyrosine phosphorylation.
@en
type
label
Activation of the lck tyrosine ...... tory tyrosine phosphorylation.
@en
prefLabel
Activation of the lck tyrosine ...... tory tyrosine phosphorylation.
@en
P2093
P2860
P356
P1476
Activation of the lck tyrosine ...... tory tyrosine phosphorylation.
@en
P2093
P2860
P304
20056-20059
P356
10.1074/JBC.274.29.20056
P407
P577
1999-07-01T00:00:00Z