about
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Evaluation of Adverse Drug Properties with Cryopreserved Human Hepatocytes and the Integrated Discrete Multiple Organ Co-culture (IdMOC(TM)) SystemFunctionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping testsSequence diversity and haplotype structure at the human CYP3A clusterDig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell linesRifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human HepatocytesGenetic variability in CYP3A5 and its possible consequences.Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse modelSummary of information on human CYP enzymes: human P450 metabolism data.The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alphaComparative study of the affinity and metabolism of type I and type II binding quinoline carboxamide analogues by cytochrome P450 3A4The human CYP3A subfamily: practical considerations.A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity.Leukemias related to treatment with DNA topoisomerase II inhibitors.Allosteric phenomena in cytochrome P450-catalyzed monooxygenations.Fatal methadone toxicity: potential role of CYP3A4 genetic polymorphism.Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.Pharmacogenetics in diverse ethnic populations--implications for drug discovery and development.Intrinsic sexually dimorphic expression of the principal human CYP3A4 correlated with suboptimal activation of GH/glucocorticoid-dependent transcriptional pathways in men.Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsAn insulin-like growth factor 1 receptor inhibitor induces CYP3A4 expression through a pregnane X receptor-independent, noncanonical constitutive androstane receptor-related mechanism.The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment.Assessing the function of genetic variants in candidate gene association studies.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Systems biology in drug safety and metabolism: integration of microarray, real-time PCR and enzyme approaches.Pharmacokinetic variability of anticancer agents.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Clinical implications of CYP3A polymorphisms.Association of CYP3A4 genotype with treatment-related leukemia.Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimusPXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessmentStructure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model.The impact of pharmacogenetics on HIV therapy.Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Pharmacologic modulation strategies to reduce dose requirements of anticancer therapy while preserving clinical efficacy.Temsirolimus: a safety and efficacy review.Enzyme induction with antiepileptic drugs: cause for concern?Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.
P2860
Q25255438-06192863-6951-4ABE-ACEC-A6EB60BD51A2Q26801904-953E2EDF-0567-4C5A-B4E1-604F688C26B9Q28260518-7F146D0E-42B0-4E38-AA5D-9F156730193FQ28284189-D6759050-2A6E-4543-8833-13063294A255Q28384643-BD3F3289-96C7-4CC4-BD36-740804B21E40Q28732720-0AD730B3-0F8F-4304-B13D-33EC7755727CQ30341330-9A06721E-0CEA-41A7-8503-93C08ED6E013Q30417522-550DCBED-DDF9-4DAE-A584-3E3F36C0E0F6Q32103802-F3F3D50E-6BF1-48B5-8AA0-FE64D778DF42Q33968352-6D738695-9045-4F0E-9BB3-9B2EF236FAB4Q34075797-7110A3B9-F513-476B-A491-491004ED99FEQ34119161-E9AC99E6-5612-43DB-BB0F-DC74285FFD9AQ34239110-75352B54-B15C-4A53-9FFF-41704A49D131Q34243503-A12A7445-2ADB-486C-9B09-50B7CE2FB6CFQ34370833-9307A92E-C5D5-42BD-BF5E-2C888675B201Q34500741-432B81CA-B547-4A4D-A28A-0EBFC37458B1Q34604457-0B4F92CC-FAD0-4A8A-90BB-C01515E68C64Q34775319-EE4F061E-A7D7-4ED2-8EA1-2B7B77FCB066Q35590828-8ED4B9E7-588F-4C1A-ACF6-5CE427030F9AQ35753588-E58B4539-981D-46D1-947D-932225707E01Q35776828-B54BB151-25D6-4053-B337-BD5B02DDDB88Q35825699-E285232D-1A16-422C-BC98-FA149C853BC8Q35842159-A8D55B49-42D1-4859-BFAB-AB24932C56C6Q35919726-410C1EC0-A1EF-4451-B657-33DDEAC63BCAQ36120843-0B317680-B956-40A3-B202-AA89B3B29233Q36146910-8D4B1ED2-4249-48B1-98E9-92D6233CD2F7Q36440155-74146962-F5F9-4DD6-B43A-298418569FE2Q36440873-D7F11632-8CE2-4B0E-B809-BEE4487559FFQ36546247-301B852F-A25B-45CF-AA54-895A75B1D0AEQ36643196-172003E6-7800-46ED-8F32-510A886B7C82Q36696454-84BF399D-25A4-4208-B8D4-96B1F1F86D42Q36995453-709FFE04-9176-4B9A-8935-0A3FC95F2C93Q37002739-F863DDEE-30CD-4784-8EBC-8C2198A4F7DCQ37207332-51C5D79A-8338-424D-9371-6A8ACE06ED01Q37405140-9545DE34-ECBA-43E1-A740-5E84D0823F69Q37592262-EA9123BF-6A74-4116-B176-3B708D9AEC78Q38024126-B5EC1F7A-7889-4E77-897F-CA1C39F93A62Q38031941-EF671FF2-21CF-47F4-8475-5473EF7A0957Q38046892-FBEC7C52-CF0E-44D0-8022-8723C3DCD450Q38170449-3E00349D-55A9-4C15-A387-41D35B181724
P2860
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Substrates of human hepatic cytochrome P450 3A4.
@en
type
label
Substrates of human hepatic cytochrome P450 3A4.
@en
prefLabel
Substrates of human hepatic cytochrome P450 3A4.
@en
P1433
P1476
Substrates of human hepatic cytochrome P450 3A4
@en
P2093
A Rasmussen
D L Kaminski
P356
10.1016/0300-483X(95)03155-9
P407
P50
P577
1995-12-01T00:00:00Z