New mechanisms of drug resistance in parasitic protozoa.
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Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancerInduction of resistance to azole drugs in Trypanosoma cruzi.Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolaeDrug targets and mechanisms of resistance in the anaerobic protozoaDrug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNAFormation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolaePhysiological consequences of drug resistance in Leishmania and their relevance for chemotherapyNitroimidazoles for the treatment of TB: past, present and futurePathways of As(III) detoxification in Saccharomyces cerevisiae.Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance.Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugsDual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniAntimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pumpHomologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegansRetention and loss of RNA interference pathways in trypanosomatid protozoansMultiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencingGeneration of Leishmania hybrids by whole genomic DNA transformationFormation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nucleaseIsolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by overexpression/selection.Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.A kinetic model for the action of a resistance efflux pump.Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance.Why metronidazole is active against both bacteria and parasites.In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.Multidrug transporters in prokaryotic and eukaryotic cells: physiological functions and transport mechanisms.Target assessment for antiparasitic drug discovery.The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.Multidrug resistance genes and p-glycoprotein in the testis of the rat, mouse, Guinea pig, and human.Protozomics: trypanosomatid parasite genetics comes of age.Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Antimony resistance in leishmania, focusing on experimental research.Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimonyP-glycoprotein structure and evolutionary homologies.Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice.Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis.
P2860
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P2860
New mechanisms of drug resistance in parasitic protozoa.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
New mechanisms of drug resistance in parasitic protozoa.
@en
type
label
New mechanisms of drug resistance in parasitic protozoa.
@en
prefLabel
New mechanisms of drug resistance in parasitic protozoa.
@en
P1476
New mechanisms of drug resistance in parasitic protozoa.
@en
P2093
P304
P356
10.1146/ANNUREV.MI.49.100195.002235
P577
1995-01-01T00:00:00Z