Mechanism of block and identification of the verapamil binding domain to HERG potassium channels.
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Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipineNitric Oxide Synthase 1 Adaptor Protein, an Emerging New Genetic Marker for QT Prolongation and Sudden Cardiac DeathhERG channel function: beyond long QTNovel roles for hERG K(+) channels in cell proliferation and apoptosisIonic mechanisms of arrhythmogenesisEvaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordanceThe KCNH2 genetic polymorphism (1956, C>T) is a novel biomarker that is associated with CCB and α,β-ADR blocker response in EH patients in ChinaElectrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1The Inhibitory Effects of Ca2+ Channel Blocker Nifedipine on Rat Kv2.1 Potassium ChannelsMaturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissuesK+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.Artifactual contractions triggered by field stimulation of cardiomyocytes.Refined docking as a valuable tool for lead optimization: application to histamine H3 receptor antagonists.Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.State-dependent blockade of human ether-a-go-go-related gene (hERG) K(+) channels by changrolin in stably transfected HEK293 cells.Comparison of the effects of antiarrhythmic drugs flecainide and verapamil on fKv1.4ΔN channel currents in Xenopus oocytesThe Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study.Complexity of ranolazine and phenytoin use in an infant with long QT syndrome type 3.A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant miceCardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discoveryRobust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.Drug-induced long QT syndromeRanolazine: ion-channel-blocking actions and in vivo electrophysiological effects.The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity.Drug-induced torsades de pointes and implications for drug development.Selective phenylalkylamine block of I(Kr) over other K(+) currents in guinea-pig ventricular myocytes.Despite increased plasma concentration, inflammation reduces potency of calcium channel antagonists due to lower binding to the rat heart.Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels.Recapitulation of an ion channel IV curve using frequency componentsLong-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias.A novel frequency analysis method for assessing K(ir)2.1 and Na (v)1.5 currents.Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent.Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
P2860
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P2860
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mechanism of block and identif ...... in to HERG potassium channels.
@en
type
label
Mechanism of block and identif ...... in to HERG potassium channels.
@en
prefLabel
Mechanism of block and identif ...... in to HERG potassium channels.
@en
P2093
P356
P1433
P1476
Mechanism of block and identif ...... in to HERG potassium channels.
@en
P2093
P304
P356
10.1161/01.RES.84.9.989
P577
1999-05-01T00:00:00Z