Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo.
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PEGylated Adenoviruses: From Mice to MonkeysPreferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injectionDifferential activation of innate immune responses by adenovirus and adeno-associated virus vectorsA Caenorhabditis elegans locomotion phenotype caused by transgenic repeats of the hlh-17 promoter sequenceNo immune responses by the expression of the yeast Ndi1 protein in ratsAdenovirus Binding to Blood Factors Results in Liver Cell Infection and HepatotoxicityPre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutininProduction of adenovirus vectors and their use as a delivery system for influenza vaccines.Development of adenoviral vector-based mucosal vaccine against influenza.V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy.GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk.Attenuated acute liver injury in mice by naked hepatocyte growth factor gene transfer into skeletal muscle with electroporation.Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells.PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile.Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice.Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors.Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by noninvasive electroporation.Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitisMacrophage inflammatory protein-2 as mediator of inflammation in acute liver injuryThe influence of innate and pre-existing immunity on adenovirus therapyPre-existing immunity and passive immunity to adenovirus 5 prevents toxicity caused by an oncolytic adenovirus vector in the Syrian hamster modelEfficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primatesBiodistribution and residence time of adenovector serotype 5 in normal and immunodeficient mice and rats detected with bioluminescent imaging.Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathwayAdenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.Gene and cell-mediated therapies for muscular dystrophy.MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus.Herpes simplex virus triggers and then disarms a host antiviral response.Adenovirus infection results in alterations of insulin signaling and glucose homeostasis.Helper-independent piggyBac plasmids for gene delivery approaches: strategies for avoiding potential genotoxic effects.Safety studies on intravenous administration of oncolytic recombinant vesicular stomatitis virus in purpose-bred beagle dogs.Vasoactive intestinal peptide increases hepatic transduction and reduces innate immune response following administration of helper-dependent Ad.Recognition of virus infection and innate host responses to viral gene therapy vectors.Development of a targeted gene vector platform based on simian adenovirus serotype 24.Evaluation of innate immunity and vector toxicity following inoculation of bovine, porcine or human adenoviral vectors in a mouse modelDepletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytesThe promise and potential hazards of adenovirus gene therapy.Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.Evaluation of biodistribution and safety of adenovirus vectors containing group B fibers after intravenous injection into baboons.
P2860
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P2860
Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Adenoviral gene therapy leads ...... endent hepatic injury in vivo.
@en
type
label
Adenoviral gene therapy leads ...... endent hepatic injury in vivo.
@en
prefLabel
Adenoviral gene therapy leads ...... endent hepatic injury in vivo.
@en
P2093
P1433
P1476
Adenoviral gene therapy leads ...... endent hepatic injury in vivo.
@en
P2093
Libermann TA
Stillman IE
P304
P356
10.1089/10430349950018364
P577
1999-04-01T00:00:00Z