Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.
about
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repressionDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentFed-state clamp stimulates cellular mechanisms of muscle protein anabolism and modulates glucose disposal in normal menReviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose HomeostasisDietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolismInhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic deathThermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiationDeficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed ratsTargeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour developmentThe TOR signaling cascade regulates gene expression in response to nutrientsHigh Leucine Diets Stimulate Cerebral Branched-Chain Amino Acid Degradation and Modify Serotonin and Ketone Body Concentrations in a Pig Model.Transcriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀ × E. lanceolatus♂)Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationPlasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.Molecular characterization of mouse gastric epithelial progenitor cells.Leucine-rich diet alters the eukaryotic translation initiation factors expression in skeletal muscle of tumour-bearing rats.Amino acids and insulin act additively to regulate components of the ubiquitin-proteasome pathway in C2C12 myotubesMonoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth.Amino-acid-dependent signal transduction.Control of translation initiation through integration of signals generated by hormones, nutrients, and exerciseBCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice.Akt/protein kinase B promotes organ growth in transgenic mice.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adultsMammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acidsRegulation of mammalian translation factors by nutrients.Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome.Role of leucine in protein metabolism during exercise and recovery.The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines.The effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo.Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs.Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosomeGlucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle.Signaling control of mRNA translation in cancer pathogenesis.Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigsMolecular events and signalling pathways involved in skeletal muscle disuse-induced atrophy and the impact of countermeasures.The tuberous sclerosis complex genes in tumor development.
P2860
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P2860
Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Leucine regulates translation ...... ation of ribosomal protein S6.
@en
type
label
Leucine regulates translation ...... ation of ribosomal protein S6.
@en
prefLabel
Leucine regulates translation ...... ation of ribosomal protein S6.
@en
P2093
P2860
P356
P1476
Leucine regulates translation ...... lation of ribosomal protein S6
@en
P2093
L S Jefferson
R L Horetsky
S R Kimball
P2860
P304
11647-11652
P356
10.1074/JBC.274.17.11647
P407
P577
1999-04-01T00:00:00Z