Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
about
RTX proteins: a highly diverse family secreted by a common mechanismThe adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain.Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussisInduction of a polarized Th1 response by insertion of multiple copies of a viral T-cell epitope into adenylate cyclase of Bordetella pertussis.Delivery of multiple epitopes by recombinant detoxified adenylate cyclase of Bordetella pertussis induces protective antiviral immunity.Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis.Bacteria modulate the CD8+ T cell epitope repertoire of host cytosol-exposed proteins to manipulate the host immune response.Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic formEnhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase.Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.Tetanus toxin L chain is processed by major histocompatibility complex class I and class II pathways and recognized by CD8+ or CD4+ T lymphocytes.Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adults.
P2860
Q24630254-74F8F8F4-6FFE-4B0F-A299-F8BA1911DDC4Q24675699-86132D76-95C0-4BF4-9A53-7DF235310BD9Q27346834-81334301-57BA-4614-B696-D6CDD02D890EQ30425161-E63E63F9-BA1E-4205-A3B4-495CA56FD36DQ30425735-17B28235-76AF-4BBD-B08F-B534620CC8F6Q33595975-3BBD53B8-3BE2-4832-9E7A-94D144BDE9F1Q33852549-8CD6B6A3-12CE-4297-8312-9C6DB163C82AQ33908773-DE0DED14-710F-456A-BA5E-4B5DB827A5C4Q34055255-3E84D96C-1A7B-4A86-AB15-6AE97706E58FQ35260287-557ED4DE-8E7F-4842-812A-273655D4BA75Q35946908-02766A2C-9B07-4B78-928A-9BA91B9E21B1Q37582898-6784583C-4CD1-4C3B-AF3D-7CC5E23DF3DEQ38317392-4742A45C-15FF-49E5-A8E6-B48EA4F16174Q39653801-5A7AE50B-E72A-4450-BF89-F6A7E59A7345Q40301344-0E72C917-1D60-4CE1-989B-8C81C1551992Q41882978-6FD984B4-BEB7-4CF6-835E-BAEA6FBBA23DQ41921483-0CE90DF9-746B-4D4C-848C-922661A9796CQ42045089-8EA1BCF4-4708-45EF-AC45-12092A2375F4
P2860
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Direct delivery of the Bordete ...... antigen presentation pathway.
@en
type
label
Direct delivery of the Bordete ...... antigen presentation pathway.
@en
prefLabel
Direct delivery of the Bordete ...... antigen presentation pathway.
@en
P2093
P1476
Direct delivery of the Bordete ...... I antigen presentation pathway
@en
P2093
G Karimova
P Guermonprez
P304
P407
P577
1999-02-01T00:00:00Z