The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.
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Nutrient-stimulated insulin secretion in mouse islets is critically dependent on intracellular pHMethyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATPParticipation of endogenous fatty acids in the secretory activity of the pancreatic B-cell2-oxocarboxylic acids and function of pancreatic islets in obese-hyperglycaemic mice. Insulin secretion in relation to 45Ca uptake and metabolismNADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretionOverexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exerciseOverexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cellsKetone bodies and islet function: 86Rb handling and metabolic data.High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediatesGlucose-sensing mechanisms in pancreatic beta-cells.Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.The stimulus-secretion coupling of glucose-induced insulin release. Metabolic events in islets stimulated by non-metabolizable secretagogues.The metabolism of 4-methyl-2-oxopentanoate in rat pancreatic islets.Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans.The biochemistry of diabetes.Glucoreceptor mechanisms and the control of insulin release and biosynthesis.Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells.Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.Suppression of adenylate kinase catalyzed phosphotransfer precedes and is associated with glucose-induced insulin secretion in intact HIT-T15 cells.Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.The dynamic plasticity of insulin production in β-cells.Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose.Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats.Activation of insulin-secreting cells by pyruvate and halogenated derivatives.Stimulation by D-glucose of mitochondrial oxidative events in islet cellsImportance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells.Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice.The coupling of metabolic to secretory events in pancreatic islets. The cytosolic redox state.Cytosolic ratios of free [NADPH]/[NADP+] and [NADH]/[NAD+] in mouse pancreatic islets, and nutrient-induced insulin secretion.Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.Mechanism of 3-phenylpyruvate-induced insulin release. Metabolic aspects.The stimulus-secretion coupling of glucose-induced insulin release. Metabolism of glucose in K+-deprived islets.Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock.Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells.Mathematical simulation of membrane processes and metabolic fluxes of the pancreatic beta-cell.
P2860
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P2860
The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
The stimulus-secretion couplin ...... us pyruvate on islet function.
@en
type
label
The stimulus-secretion couplin ...... us pyruvate on islet function.
@en
prefLabel
The stimulus-secretion couplin ...... us pyruvate on islet function.
@en
P2093
P2860
P356
P1433
P1476
The stimulus-secretion couplin ...... us pyruvate on islet function.
@en
P2093
Boschero AC
Herchuelz A
Malaisse WJ
P2860
P304
P356
10.1042/BJ1760217
P407
P577
1978-10-01T00:00:00Z