Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21.
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The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complexThe BTG2 protein is a general activator of mRNA deadenylationBtg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylationArrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcriptionPhosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformationCrystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activityControl of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 GenesB-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signalingPhosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarrayRegulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma.BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.Endogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients.B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NFκB pathways which enhances transcription of MnSOD by accelerating IκBα degradation in normal and cancer cells.Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells.Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes.Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins.Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor.TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop.B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage.Molecular characterization, expression pattern and association analysis of the porcine BTG2 gene.Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells.BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells.Inhibition of TNFα-interacting protein α (Tipα)-associated gastric carcinogenesis by BTG2/TIS21 via downregulating cytoplasmic nucleolin expression.Estradiol Prevents High Glucose-Induced β-cell Apoptosis by Decreased BTG2 Expression
P2860
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P2860
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Induction of growth inhibition ...... ue to overexpression of TIS21.
@en
type
label
Induction of growth inhibition ...... ue to overexpression of TIS21.
@en
prefLabel
Induction of growth inhibition ...... ue to overexpression of TIS21.
@en
P2093
P2860
P1476
Induction of growth inhibition ...... ue to overexpression of TIS21.
@en
P2093
P2860
P356
10.1002/(SICI)1098-2744(199809)23:1<25::AID-MC4>3.0.CO;2-G
P577
1998-09-01T00:00:00Z