Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.
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Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cellsDistinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1Neurons are MHC class I-dependent targets for CD8 T cells upon neurotropic viral infectionMicroglia retard dengue virus-induced acute viral encephalitisSpecific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection.Virus-Specific CD8+ Lymphocytes Share the Same Effector-Memory Phenotype but Exhibit Functional Differences in Acute Hepatitis B and CComplex adaptive immunity to enteric fevers in humans: lessons learned and the path forwardImmune Surveillance of the CNS following Infection and InjurySerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageThe SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Alveolar epithelial cell chemokine expression triggered by antigen-specific cytolytic CD8(+) T cell recognition.Type II pneumocyte-CD8+ T-cell interactions. Relationship between target cell cytotoxicity and activation.Asthma increases susceptibility to heterologous but not homologous secondary influenzaRole of LAT in the granule-mediated cytotoxicity of CD8 T cells.Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTLMucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injuryToward improved immunocompetence of adoptively transferred CD8+ T cellsNK cells and apoptosis.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines.A role for perforin in downregulating T-cell responses during chronic viral infection.Fas (CD95)-dependent cell-mediated immunity to Listeria monocytogenes.Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R{alpha} (CD127) and perforin expression.Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice.Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice.Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequencesCD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing.Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus.CD8(+) T lymphocytes mediate Borna disease virus-induced immunopathology independently of perforinEpidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B viruses.Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection.How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi?Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis BGranzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infectionHypocalcaemia, alcohol drinking and viroimmune responses in ART recipients.Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms.Baculovirus capsid display potentiates OVA cytotoxic and innate immune responses.New flow cytometric assays for monitoring cell-mediated cytotoxicityA DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.
P2860
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P2860
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Molecular mechanisms of lympho ...... tion and pathogenesis in vivo.
@en
type
label
Molecular mechanisms of lympho ...... tion and pathogenesis in vivo.
@en
prefLabel
Molecular mechanisms of lympho ...... tion and pathogenesis in vivo.
@en
P2093
P1476
Molecular mechanisms of lympho ...... tion and pathogenesis in vivo.
@en
P2093
Hengartner H
Ledermann B
Zinkernagel RM
P304
P356
10.1146/ANNUREV.IMMUNOL.14.1.207
P577
1996-01-01T00:00:00Z