Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
about
Advances in preclinical investigation of prostate cancer gene therapy.In situ use of suicide genes for therapy of brain tumours.A fiber-modified adenovirus co-expressing HSV-TK and Coli.NTR enhances antitumor activities in breast cancer cells.Prodrug-activating systems in suicide gene therapy.Prodrug activation enzymes in cancer gene therapy.Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect.Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer.Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives.Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.Gene therapy for carcinoma of the breast.T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient miceStem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model.Specific targeting of gene therapy to prostate cancer using a two-step transcriptional amplification systemCombined enzyme/prodrug treatment by genetically engineered AT-MSC exerts synergy and inhibits growth of MDA-MB-231 induced lung metastasesA novel double-enhanced suicide gene therapy in a colon cancer cell line mediated by gef and apoptin.Mesenchymal stem cells: A new platform for targeting suicide genes in cancer.Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells.Human natural killer cell line modified with a chimeric immunoglobulin T-cell receptor gene leads to tumor growth inhibition in vivo.Suicide gene therapy for premalignant disease: a new strategy for the treatment of intraepithelial neoplasia.Cancer gene therapy with HSV-tk/GCV system depends on T-cell-mediated immune responses and causes apoptotic death of tumor cells in vivo.Enhanced suicide gene effect by adenoviral transduction of a VP22-cytosine deaminase (CD) fusion gene.TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells.Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model.The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice.Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice.Antitumor effects of cytosine deaminase and thymidine kinase fusion suicide gene under the control of mdr1 promoter in mdr1 positive leukemia cells.Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity.The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.
P2860
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P2860
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Double suicide gene (cytosine ...... nation of tumor cells in vivo.
@en
type
label
Double suicide gene (cytosine ...... nation of tumor cells in vivo.
@en
prefLabel
Double suicide gene (cytosine ...... nation of tumor cells in vivo.
@en
P2093
P356
P1433
P1476
Double suicide gene (cytosine ...... nation of tumor cells in vivo.
@en
P2093
Blankenstein T
Kammertöns T
Schendel DJ
P304
P356
10.1089/HUM.1998.9.6-855
P577
1998-04-01T00:00:00Z