An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
about
Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and BimATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage responseProapoptotic Bid mediates the Atr-directed DNA damage response to replicative stressBID binds to replication protein A and stimulates ATR function following replicative stressTargeting DNA topoisomerase II in cancer chemotherapyMCL-1 localizes to sites of DNA damage and regulates DNA damage responseObatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage.Targeting mcl-1 for radiosensitization of pancreatic cancers.MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.Idelalisib and bendamustine combination is synergistic and increases DNA damage response in chronic lymphocytic leukemia cells.The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication.Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1.Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide.Chk1 activity is required for BAK multimerization in association with PUMA during mitochondrial apoptosis.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage.Etoposide induces cell death via mitochondrial-dependent actions of p53.Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint.Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence.The prognostic significance of MCL1 copy number gain in esophageal squamous cell carcinoma.Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.Simultaneous targeting of ATM and Mcl-1 increases cisplatin sensitivity of cisplatin-resistant non-small cell lung cancer.An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines
P2860
Q24301935-DDDA5A61-9DEA-42C0-A297-057023549ACEQ24312475-9DFA8363-230A-424C-BA3C-FBAA0CF3C25AQ24620829-994F7335-AEE3-41D2-AA9C-5FDDE38C99EAQ24631191-9B5B378A-C1C3-4106-9D48-F3DC30506CA8Q24649711-1CF504AF-F5DF-493C-A454-D3990122B8C0Q34582160-DCBCC5B6-9FC4-4443-A7C9-44268F7C8425Q35007971-213A6F1F-9BC2-4AEB-B2D8-563E824049BAQ35150651-3F98EB36-0CC2-43F6-ACE9-E0869EF34392Q36184998-5877049A-06B1-4FBD-8E3E-591CC68FE20AQ37725415-85AB9E1A-33EA-479F-909F-F0D2A1C364ECQ38722941-211AF150-8C1B-49B5-9F11-0D44948298F2Q38846360-D44AEC71-5A70-431E-8625-E5BD2253ACFCQ39713463-0BB59200-E44A-4A91-A829-9865145B84EDQ40358178-10545D35-35BB-4F63-92C2-E182B97F6062Q41694352-D6523F91-26AA-4BED-8BBD-F05C25BC44FDQ41845149-6D2712EB-171D-4693-9A98-4BC0F28CBF3CQ41850633-EAEF8311-7375-46B6-99BA-4B19E93425D5Q41959713-9E9C0930-45DD-41CD-A679-A0760E92F8B9Q42254401-C0AD9197-173B-46F4-80A9-BD542F0EF8DAQ46922752-1CB7313E-0E2B-4B9B-B960-B7229B9EDC9FQ47308626-F94AA397-1013-4F9C-BD39-C343135A1D5EQ53733720-1C4328A7-0C58-4CF5-A3F1-7EC634E60F7DQ58695175-660F12D3-EC83-4447-A88B-B1D689D5902A
P2860
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
@en
type
label
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
@en
prefLabel
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
@en
P2093
P2860
P356
P1476
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
@en
P2093
Payman Hojabrpour
Sarwat Jamil
Shadi Mojtabavi
Stefanie Cheah
Vincent Duronio
P2860
P304
P356
10.1091/MBC.E07-11-1171
P577
2008-05-21T00:00:00Z