FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. - Wikidata - awgldk - TriplyDB

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

http://www.wikidata.org/entity/Q41085784

about

150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8 Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling DEDD, a novel death effector domain-containing protein, targeted to the nucleolus Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum Caspases: pharmacological manipulation of cell death Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7 DED or alive: assembly and regulation of the death effector domain complexes Regulation of CD95/Fas signaling at the DISC Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8 Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain The role of c-FLIP in modulation of CD95-induced apoptosis Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis Two CD95 (APO-1/Fas) signaling pathways The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats.Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.Anticancer activity of Nelumbo nucifera stamen extract in human colon cancer HCT-116 cells in vitro.Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling A new caspase-8 isoform caspase-8s increased sensitivity to apoptosis in Jurkat cells The potential for monocyte-mediated immunotherapy during infection and malignancy. Part I: apoptosis induction and cytotoxic mechanisms.Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules.Identification of a secondary promoter of CASP8 and its related transcription factor PURα Trypanosoma cruzi posttranscriptionally up-regulates and exploits cellular FLIP for inhibition of death-inducing signal.DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB.Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.

P2860

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P2860

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

http://www.wikidata.org/entity/Q41085784

description

1997 nî lūn-bûn

@nan

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

1997年论文

@zh

1997年论文

@zh-cn

name

FLICE is predominantly express ...... , caspase-8/a and caspase-8/b.

@en

type

label

FLICE is predominantly express ...... , caspase-8/a and caspase-8/b.

@en

prefLabel

FLICE is predominantly express ...... , caspase-8/a and caspase-8/b.

@en

P1433

Q41085784-0417D092-E295-458A-BA2B-8699C197B5A0

P1476

Q41085784-4BE586FD-6821-4AD2-AB5D-3F1A1540933C

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P2860

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P698

Q41085784-219E2175-63CC-4676-8AC6-A1EF07305FA2

P356

JBC.272.43.26953

P1433

Journal of Biological Chemistry

P1476

FLICE is predominantly express ...... s, caspase-8/a and caspase-8/b

@en

P2093

C Scaffidi

http://www.w3.org/2001/XMLSchema#string

J P Medema

http://www.w3.org/2001/XMLSchema#string

P H Krammer

http://www.w3.org/2001/XMLSchema#string

P2860

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities

Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32

ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis

ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B

Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases

Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

P304

26953-26958

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P31

scholarly article

P356

10.1074/JBC.272.43.26953

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P407

P433

43

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P478

272

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P50

Marcus E. Peter

P577

1997-10-01T00:00:00Z

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P5875

13887475

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P698

9341131

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