Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies.
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Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoidHuman eosinophils express the high affinity IgE receptor, FcεRI, in bullous pemphigoidTwo forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomainImmunopathology and molecular diagnosis of autoimmune bullous diseasesThe IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsoneCollagen XVII is destabilized by a glycine substitution mutation in the cell adhesion domain Col15Prevalence of pemphigus and pemphigoid autoantibodies in the general populationBullous pemphigoid sera react specifically with various domains of BP230, most frequently with C-terminal domain, by immunoblot analyses using bacterial recombinant proteins covering the entire molecule.Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigenInduction of dermal-epidermal separation in mice by passive transfer of antibodies specific to type VII collagen.Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid.New laboratory techniques for the assessment of acquired immunobullous disorders.Mucous membrane pemphigoid with generalized blisters: IgA and IgG autoantibodies target both laminin-332 and type XVII collagen.The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases.Usefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous PemphigoidFunctional characterization of an IgE-class monoclonal antibody specific for the bullous pemphigoid autoantigen, BP180.The role of T cells in cutaneous autoimmune disease.The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseasesA critical role for neutrophil elastase in experimental bullous pemphigoidMissing the target: characterization of bullous pemphigoid patients who are negative using the BP180 enzyme-linked immunosorbant assay.Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls.Pemphigoid diseases: pathogenesis, diagnosis, and treatment.Bullous pemphigoid: role of complement and mechanisms for blister formation within the lamina lucida.Collagen XVII: a shared antigen in neurodermatological interactions?Blistering disease: insight from the hemidesmosome and other components of the dermal-epidermal junction.Role of different pathways of the complement cascade in experimental bullous pemphigoid.IgE-mediated mechanisms in bullous pemphigoid and other autoimmune bullous diseases.Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.Bullous Pemphigoid: A Review of its Diagnosis, Associations and Treatment.Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm.Eosinophil localization to the basement membrane zone is autoantibody- and complement-dependent in a human cryosection model of bullous pemphigoid.Autoimmune subepidermal blistering diseases in Uganda: correlation of autoantibody class with age of patients.Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases.IgE auto-reactivity in bullous pemphigoid: eosinophils and mast cells as major targets of pathogenic immune reactants.IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid.Serum levels of immunoglobulins G1 and G4 targeting the non-collagenous 16A domain of BP180 reflect bullous pemphigoid activity and predict bad prognosis.Biochip technology for the serological diagnosis of bullous pemphigoid.Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model.Alterations of collagen XVII expression during transformation of oral epithelium to dysplasia and carcinoma.The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis.
P2860
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P2860
Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Tight clustering of extracellu ...... ous pemphigoid autoantibodies.
@en
type
label
Tight clustering of extracellu ...... ous pemphigoid autoantibodies.
@en
prefLabel
Tight clustering of extracellu ...... ous pemphigoid autoantibodies.
@en
P2093
P1476
Tight clustering of extracellu ...... ous pemphigoid autoantibodies.
@en
P2093
Balding SD
Giudice GJ
Olague-Marchan M
Zillikens D
P2888
P304
P356
10.1111/1523-1747.EP12337492
P407
P577
1997-10-01T00:00:00Z
P5875
P6179
1034252612