Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
about
Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-bindingTranscription factor-based biosensors enlightened by the analyteCombination therapies for combating antimicrobial resistanceA crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyraseThe crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove bindingA New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of InhibitionApplication of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VIIdentification of novel bacterial DNA gyrase inhibitors: An in silico studyGenome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2(T) from Lop Nor region, China.Mechanism of inhibition of DNA gyrase by ES-1273, a novel DNA gyrase inhibitor.Assessing sensitivity to antibacterial topoisomerase II inhibitors.Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors.Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.Protective effect of Qnr on agents other than quinolones that target DNA gyrase.The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.Diversity of Natural Product Biosynthetic Genes in the Microbiome of the Deep Sea Sponges Inflatella pellicula, Poecillastra compressa, and Stelletta normani.In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.Antibiotics from microbes: converging to kill.Update on carbohydrate-containing antibacterial agents.The TetR family of regulators.Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase.Bifunctional antimicrobial conjugates and hybrid antimicrobials.Two transcription factors, CabA and CabR, are independently involved in multilevel regulation of the biosynthetic gene cluster encoding the novel aminocoumarin, cacibiocin.SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase.Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents.Crystallization and preliminary X-ray analysis of the TetR-like efflux pump regulator SimR.Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.The phytotoxin albicidin is a novel inhibitor of DNA gyrase.DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties.Opposing effects of aminocoumarins and fluoroquinolones on the SOS response and adaptability in Staphylococcus aureus.Structural insights into simocyclinone as an antibiotic, effector ligand, and substrate.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.DNA Topoisomerases as Targets for Antibacterial Agents.Topoisomerases as anticancer targets.Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors.The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium.Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.
P2860
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P2860
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
@en
type
label
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
@en
prefLabel
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
@en
P2093
P2860
P1476
Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.
@en
P2093
Alison J Howells
Hans-Peter Fiedler
Ruth H Flatman
P2860
P304
P356
10.1128/AAC.49.3.1093-1100.2005
P407
P577
2005-03-01T00:00:00Z