Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis.
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Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsIdentification and functional characterization of voltage-dependent calcium channels in T lymphocytesCa2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit geneA structural basis for drug-induced long QT syndromeVoltage-dependent acceleration of Ca(v)1.2 channel current decay by (+)- and (-)-isradipineA genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channelsOpposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain.Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.Functional architecture of the inner pore of a voltage-gated Ca2+ channel.Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-L-type Ca2+ channelCalcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine bindingEstrogens directly potentiate neuronal L-type Ca2+ channels.Ca²⁺ channels and praziquantel: a view from the free worldThe role of region IVS5 of the human cardiac calcium channel in establishing inactivated channel conformation: use-dependent block by benzothiazepines.Coupling of excitation to Ca2+ release is modulated by dysferlin.Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.Conserved Ca2+-antagonist-binding properties and putative folding structure of a recombinant high-affinity dihydropyridine-binding domain.Molecular simulations study of novel 1,4-dihydropyridines derivatives with a high selectivity for Cav3.1 calcium channel.Structural model for dihydropyridine binding to L-type calcium channels.Serine residue in the IIIS5-S6 linker of the L-type Ca2+ channel alpha 1C subunit is the critical determinant of the action of dihydropyridine Ca2+ channel agonists.Structure-function characterization of the human mitochondrial thiamin pyrophosphate transporter (hMTPPT; SLC25A19): Important roles for Ile(33), Ser(34), Asp(37), His(137) and Lys(291).L-type Ca2+ channels in fetal and adult ovine cerebral arteries.Mechanism of dihydropyridine interaction with critical binding residues of L-type Ca2+ channel alpha 1 subunits.An amino acid residue whose change by mutation affects drug binding to the HERG channel.DHP-insensitive L-type-like Ca channel of ascidian acquires sensitivity to DHP with single amino acid change in domain III P-region.Molecular basis for Kv1.5 channel block: conservation of drug binding sites among voltage-gated K+ channels.Cloning and functional expression of a voltage-gated calcium channel alpha1 subunit from jellyfish.A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines.Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation.Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity.
P2860
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P2860
Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Analysis of the dihydropyridin ...... alanine-scanning mutagenesis.
@en
type
label
Analysis of the dihydropyridin ...... alanine-scanning mutagenesis.
@en
prefLabel
Analysis of the dihydropyridin ...... alanine-scanning mutagenesis.
@en
P2093
P2860
P356
P1476
Analysis of the dihydropyridin ...... alanine-scanning mutagenesis.
@en
P2093
Catterall WA
Hockerman GH
Johnson BD
Peterson BZ
P2860
P304
18752-18758
P356
10.1074/JBC.272.30.18752
P407
P577
1997-07-01T00:00:00Z