Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation.
about
Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activityVariably modulated gating of the 26S proteasome by ATP and polyubiquitinCells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survivalRetroviruses have differing requirements for proteasome function in the budding processThe selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic dosesA novel mechanism for the regulation of amyloid precursor protein metabolismEpoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activityThe roles of protein expression in synaptic plasticity and memory consolidationThe immunoproteasome and viral infection: a complex regulator of inflammationMajor histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidaseThe ubiquitin-proteasome system in Alzheimer's diseasePim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseThe ubiquitin-proteasome pathway and proteasome inhibitorsEeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathwaysAccelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthaseN-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2Why does threonine, and not serine, function as the active site nucleophile in proteasomes?Proteasome activator enhances survival of Huntington's disease neuronal model cellsDosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1.Proteasome inhibitors and cardiac cell growthTripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosisThe age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogasterNeural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degenerationProteasome inhibitors block development of Plasmodium spp.Proteolysis and class I major histocompatibility complex antigen presentation.Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins.Proteasome activity is required for anthrax lethal toxin to kill macrophagesAutophagy in yeast: mechanistic insights and physiological function.Interferon-γ induces immunoproteasomes and the presentation of MHC I-associated peptides on human salivary gland cells.Proteasome inhibitors: from in vitro uses to clinical trials.Beta 2 subunit propeptides influence cooperative proteasome assembly.Equine infectious anemia virus and the ubiquitin-proteasome system.Inhibition of hepatitis B virus replication by interferon requires proteasome activityThe proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain.PSMD9 expression predicts radiotherapy response in breast cancer.Proteasome inhibitor lactacystin enhances cisplatin cytotoxicity by increasing endoplasmic reticulum stress-associated apoptosis in HeLa cells.Corneal wound healing is compromised by immunoproteasome deficiency.Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation.Characterization of Osterix protein stability and physiological role in osteoblast differentiation.Effects of N-stearoyl-L-tyrosine on the hippocampal ubiquitin-proteasome system in rats with chronic cerebral hypoperfusion.
P2860
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P2860
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Lactacystin and clasto-lactacy ...... class I antigen presentation.
@en
type
label
Lactacystin and clasto-lactacy ...... class I antigen presentation.
@en
prefLabel
Lactacystin and clasto-lactacy ...... class I antigen presentation.
@en
P2093
P2860
P356
P1476
Lactacystin and clasto-lactacy ...... class I antigen presentation.
@en
P2093
Fenteany G
Gaczynska M
Goldberg AL
P2860
P304
13437-13445
P356
10.1074/JBC.272.20.13437
P407
P577
1997-05-01T00:00:00Z