Stabilization of Glucocerebrosidase by Active Site Occupancy.

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Structure-Activity Studies of N-Butyl-1-deoxynojirimycin (NB-DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2.In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.

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Stabilization of Glucocerebrosidase by Active Site Occupancy.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

Stabilization of Glucocerebrosidase by Active Site Occupancy.

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Stabilization of Glucocerebrosidase by Active Site Occupancy.

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Stabilization of Glucocerebrosidase by Active Site Occupancy.

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P1476

Stabilization of Glucocerebrosidase by Active Site Occupancy

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P2093

Boris Bleijlevens

http://www.w3.org/2001/XMLSchema#string

Cindy P A A van Roomen

http://www.w3.org/2001/XMLSchema#string

Marcellus Ubbink

http://www.w3.org/2001/XMLSchema#string

Marielle J F M van Kooten

http://www.w3.org/2001/XMLSchema#string

Roelof Ottenhoff

http://www.w3.org/2001/XMLSchema#string

Saskia Scheij

http://www.w3.org/2001/XMLSchema#string

Saskia V Oussoren

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P2860

LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

Glucocerebrosidase is shaking up the synucleinopathies

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases

Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase

Protein stability induced by ligand binding correlates with changes in protein flexibility.

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scholarly article

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10.1021/ACSCHEMBIO.7B00276

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2017-05-22T00:00:00Z

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28485919

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5525105

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Stabilization of Glucocerebrosidase by Active Site Occupancy.

about

P2860

P2860

Stabilization of Glucocerebrosidase by Active Site Occupancy.

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P1433

P1476

P2093

P2860

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P932

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P698

P932