Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain.
about
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domainsHuman cytomegalovirus resistance to antiviral drugsMechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activityProcessing of lagging-strand intermediates in vitro by herpes simplex virus type 1 DNA polymeraseResistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementKinetic approaches to understanding the mechanisms of fidelity of the herpes simplex virus type 1 DNA polymerasephi29 DNA polymerase residue Ser122, a single-stranded DNA ligand for 3'-5' exonucleolysis, is required to interact with the terminal protein.Mutational analysis of the 3'-->5' proofreading exonuclease of Escherichia coli DNA polymerase IIIEffects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant.3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity.A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactorMechanisms by which herpes simplex virus DNA polymerase limits translesion synthesis through abasic sites.Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs.Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision.Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA.Impaired mismatch extension by a herpes simplex DNA polymerase mutant with an editing nuclease defect.The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication.Contribution of the 3'- to 5'-exonuclease activity of herpes simplex virus type 1 DNA polymerase to the fidelity of DNA synthesis.HSV-1 DNA Polymerase RNase H Activity Acts in a 3' -5' Direction and is Dependent on the 3' -5' Exonuclease Active Site.Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
P2860
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P2860
Herpes simplex virus type 1 DNA polymerase. Mutational analysis of the 3'-5'-exonuclease domain.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Herpes simplex virus type 1 DN ...... the 3'-5'-exonuclease domain.
@en
type
label
Herpes simplex virus type 1 DN ...... the 3'-5'-exonuclease domain.
@en
prefLabel
Herpes simplex virus type 1 DN ...... the 3'-5'-exonuclease domain.
@en
P2860
P356
P1476
Herpes simplex virus type 1 DN ...... the 3'-5'-exonuclease domain.
@en
P2093
P2860
P304
29245-29254
P356
10.1074/JBC.271.46.29245
P407
P577
1996-11-01T00:00:00Z