Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
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Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulationMolecular basis for activation of G protein-coupled receptor kinasesCalmodulin is a phospholipase C-beta interacting proteinA predicted amphipathic helix mediates plasma membrane localization of GRK5Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domainsG-protein-coupled receptor kinases in inflammation and diseaseThe solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunitsThe GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservationEndogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cellsAtomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor KinasesAlterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exerciseThe expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development.Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor.G-protein coupled receptor kinases as modulators of G-protein signalling.The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function.The D153del mutation in GNB3 gene causes tissue specific signalling patterns and an abnormal renal morphology in Rge chickens.Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRsGRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.Distinct structural features of G protein-coupled receptor kinase 5 (GRK5) regulate its nuclear localization and DNA-binding ability.Membrane orientation and binding determinants of G protein-coupled receptor kinase 5 as assessed by combined vibrational spectroscopic studies.S-nitrosylation-regulated GPCR signaling.G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling.GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesisG protein-coupled receptor kinases: more than just kinases and not only for GPCRsActivation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates.The origin and evolution of G protein-coupled receptor kinases.G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro.Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed InhibitorThe evolving impact of g protein-coupled receptor kinases in cardiac health and diseaseG protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension."Canonical and non-canonical actions of GRK5 in the heart"Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases.G-protein-coupled receptor kinase 2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling.A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases.GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.Unveiling the membrane-binding properties of N-terminal and C-terminal regions of G protein-coupled receptor kinase 5 by combined optical spectroscopies.
P2860
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P2860
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Phosphatidylinositol 4,5-bisph ...... inguishes the GRK subfamilies.
@en
type
label
Phosphatidylinositol 4,5-bisph ...... inguishes the GRK subfamilies.
@en
prefLabel
Phosphatidylinositol 4,5-bisph ...... inguishes the GRK subfamilies.
@en
P2093
P2860
P356
P1476
Phosphatidylinositol 4,5-bisph ...... inguishes the GRK subfamilies.
@en
P2093
Fredericks ZL
Lefkowitz RJ
Pitcher JA
Premont RT
Stoffel RH
P2860
P304
24907-24913
P356
10.1074/JBC.271.40.24907
P407
P577
1996-10-01T00:00:00Z