Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.
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Elucidating the molecular architecture of adaptation via evolve and resequence experimentsThe causes of epistasisEnvironmental changes bridge evolutionary valleysReverse evolution leads to genotypic incompatibility despite functional and active site convergenceDetecting High-Order Epistasis in Nonlinear Genotype-Phenotype MapsEvolutionary rescue from extinction is contingent on a lower rate of environmental change.Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype spaceEffects of new mutations on fitness: insights from models and data.Fisher's geometrical model emerges as a property of complex integrated phenotypic networksInitial mutations direct alternative pathways of protein evolutionEffect of the Bacillus atrophaeus subsp. globigii Spo0F H101R mutation on strain fitnessThe consistency of beneficial fitness effects of mutations across diverse genetic backgrounds.The environment affects epistatic interactions to alter the topology of an empirical fitness landscapeThe impact of macroscopic epistasis on long-term evolutionary dynamicsFunctional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli.Properties of selected mutations and genotypic landscapes under Fisher's geometric model.Exploiting the Adaptation Dynamics to Predict the Distribution of Beneficial Fitness Effects.Seeking Goldilocks During Evolution of Drug Resistance.Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Mutation-biased adaptation in Andean house wrens.Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation.Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatednessEnvironment determines epistatic patterns for a ssDNA virus.Dynamics and constraints of enzyme evolution.Fighting microbial drug resistance: a primer on the role of evolutionary biology in public healthMutational biases influence parallel adaptation.Epistasis and the Evolution of Antimicrobial Resistance.The cost of copy number in a selfish genetic element: the 2-μm plasmid of Saccharomyces cerevisiae.A reduced genome decreases the host carrying capacity for foreign DNA.On the Causes of Evolutionary Transition:Transversion Bias.Enhanced Survival of Rifampin- and Streptomycin-Resistant Escherichia coli Inside Macrophages.The fitness effect of mutations across environments: Fisher's geometrical model with multiple optima.Herbicide cycling has diverse effects on evolution of resistance in Chlamydomonas reinhardtii.Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa.Testing the role of genetic background in parallel evolution using the comparative experimental evolution of antibiotic resistance.Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymeraseBistability in feedback circuits as a byproduct of evolution of evolvability.Competition and fixation of cohorts of adaptive mutations under Fisher geometrical modelGenetic background affects epistatic interactions between two beneficial mutations.
P2860
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P2860
Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Diminishing returns from benef ...... nce in Pseudomonas aeruginosa.
@en
type
label
Diminishing returns from benef ...... nce in Pseudomonas aeruginosa.
@en
prefLabel
Diminishing returns from benef ...... nce in Pseudomonas aeruginosa.
@en
P2093
P2860
P1433
P1476
Diminishing returns from benef ...... nce in Pseudomonas aeruginosa.
@en
P2093
G G Perron
R C MacLean
P2860
P304
P356
10.1534/GENETICS.110.123083
P407
P577
2010-09-27T00:00:00Z