Inactivation of EF-hands makes GCAP-2 (p24) a constitutive activator of photoreceptor guanylyl cyclase by preventing a Ca2+-induced "activator-to-inhibitor" transition.
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The diversity of calcium sensor proteins in the regulation of neuronal functionNeuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signallingGenetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophiesThree-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclasesIntegrative Signaling Networks of Membrane Guanylate Cyclases: Biochemistry and PhysiologyConstitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degenerationThe neuronal calcium sensor family of Ca2+-binding proteinsStructural insights for activation of retinal guanylate cyclase by GCAP1Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1.Diversity of conformational states and changes within the EF-hand protein superfamily.Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directionsCa(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases.Ceramide kinase-like (CERKL) interacts with neuronal calcium sensor proteins in the retina in a cation-dependent manner.cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses.Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrityBiochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy.Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptationCa(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review.Calcium-myristoyl Tug is a new mechanism for intramolecular tuning of calcium sensitivity and target enzyme interaction for guanylyl cyclase-activating protein 1: dynamic connection between N-fatty acyl group and EF-hand controls calcium sensitivityActivation and inhibition of photoreceptor guanylyl cyclase by guanylyl cyclase activating protein 1 (GCAP-1): the functional role of Mg2+/Ca2+ exchange in EF-hand domainsStructure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State.Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase.Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1).Between promiscuity and specificity: novel roles of EF-hand calcium sensors in neuronal Ca2+ signalling.Understanding the physiological roles of the neuronal calcium sensor proteins.Visinin-Like Protein-3 Modulates the Interaction Between Cytochrome b 5 and NADH-Cytochrome b 5 Reductase in a Ca2+-Dependent Manner.Binding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands.Ca2+ and Mg2+ binding properties of GCAP-1. Evidence that Mg2+-bound form is the physiological activator of photoreceptor guanylyl cyclase.Mapping sites in guanylyl cyclase activating protein-1 required for regulation of photoreceptor membrane guanylyl cyclases.Mapping functional domains of the guanylate cyclase regulator protein, GCAP-2.Calcium binding, but not a calcium-myristoyl switch, controls the ability of guanylyl cyclase-activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase.Interaction of GCAP1 with retinal guanylyl cyclase and calcium: sensitivity to fatty acylation.Activation of retinal guanylyl cyclase-1 by Ca2+-binding proteins involves its dimerization.Instead of binding calcium, one of the EF-hand structures in guanylyl cyclase activating protein-2 is required for targeting photoreceptor guanylyl cyclase.A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice.Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity.Identification of proximate regions in a complex of retinal guanylyl cyclase 1 and guanylyl cyclase-activating protein-1 by a novel mass spectrometry-based method.Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.Ca(2+)-dependent conformational changes in guanylyl cyclase-activating protein 2 (GCAP-2) revealed by site-specific phosphorylation and partial proteolysis.Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina.
P2860
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P2860
Inactivation of EF-hands makes GCAP-2 (p24) a constitutive activator of photoreceptor guanylyl cyclase by preventing a Ca2+-induced "activator-to-inhibitor" transition.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Inactivation of EF-hands makes ...... ator-to-inhibitor" transition.
@en
type
label
Inactivation of EF-hands makes ...... ator-to-inhibitor" transition.
@en
prefLabel
Inactivation of EF-hands makes ...... ator-to-inhibitor" transition.
@en
P2860
P356
P1476
Inactivation of EF-hands makes ...... ator-to-inhibitor" transition.
@en
P2093
P2860
P304
19346-19350
P356
10.1074/JBC.271.32.19346
P407
P577
1996-08-01T00:00:00Z