Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity.
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Natriuretic peptide receptor A activation stabilizes a membrane-distal dimer interfaceThe linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase CProtein and Signaling Networks in Vertebrate Photoreceptor CellsCrystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclaseStructural insights for activation of retinal guanylate cyclase by GCAP1Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1.A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1The S helix mediates signal transmission as a HAMP domain coiled-coil extension in the NarX nitrate sensor from Escherichia coli K-12.Insights into the role of RD3 in guanylate cyclase trafficking, photoreceptor degeneration, and Leber congenital amaurosis.Activation of retinal guanylyl cyclase RetGC1 by GCAP1: stoichiometry of binding and effect of new LCA-related mutationsNovel functions of photoreceptor guanylate cyclases revealed by targeted deletionNeurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling.Membrane Guanylate Cyclase catalytic Subdomain: Structure and Linkage with Calcium Sensors and BicarbonateDivalent cations and redox conditions regulate the molecular structure and function of visinin-like protein-1Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptorsEvaluating the role of retinal membrane guanylyl cyclase 1 (RetGC1) domains in binding guanylyl cyclase-activating proteins (GCAPs)Ca(2+)-sensors and ROS-GC: interlocked sensory transduction elements: a review.Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface.Bicarbonate and Ca(2+) Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically.Determining consequences of retinal membrane guanylyl cyclase (RetGC1) deficiency in human Leber congenital amaurosis en route to therapy: residual cone-photoreceptor vision correlates with biochemical properties of the mutantsStructure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State.Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases.Signal transducing membrane complexes of photoreceptor outer segments.Effects of Ca2+, Mg2+, and myristoylation on guanylyl cyclase activating protein 1 structure and stabilityConstitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.Functional study of two biochemically unusual mutations in GUCY2D Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas.Identification of target binding site in photoreceptor guanylyl cyclase-activating protein 1 (GCAP1).Nitric oxide-induced conformational changes in soluble guanylate cyclaseFunctional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.Retinal degeneration 3 (RD3) protein inhibits catalytic activity of retinal membrane guanylyl cyclase (RetGC) and its stimulation by activating proteins.Characterization of a novel signal transducer element intrinsic to class IIIa/b adenylate cyclases and guanylate cyclases.Binding of guanylyl cyclase activating protein 1 (GCAP1) to retinal guanylyl cyclase (RetGC1). The role of individual EF-hands.Ca2+ and Mg2+ binding properties of GCAP-1. Evidence that Mg2+-bound form is the physiological activator of photoreceptor guanylyl cyclase.Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca(2+)-sensitivity.Dysfunction of outer segment guanylate cyclase caused by retinal disease related mutations.Expression, purification, and characterization of the intra-cellular domain of the ANP receptor.The S-helix determines the signal in a Tsr receptor/adenylyl cyclase reporter.Instead of binding calcium, one of the EF-hand structures in guanylyl cyclase activating protein-2 is required for targeting photoreceptor guanylyl cyclase.Guanylyl cyclase-activating proteins (GCAPs) are Ca2+/Mg2+ sensors: implications for photoreceptor guanylyl cyclase (RetGC) regulation in mammalian photoreceptors.Phenotypic characterization of a Chinese family with autosomal dominant cone-rod dystrophy related to GUCY2D.
P2860
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P2860
Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Interactions within the coiled ...... rather than for high affinity.
@en
Interactions within the coiled ...... rather than for high affinity.
@nl
type
label
Interactions within the coiled ...... rather than for high affinity.
@en
Interactions within the coiled ...... rather than for high affinity.
@nl
prefLabel
Interactions within the coiled ...... rather than for high affinity.
@en
Interactions within the coiled ...... rather than for high affinity.
@nl
P2093
P2860
P356
P1476
Interactions within the coiled ...... rather than for high affinity.
@en
P2093
P2860
P304
26218-26229
P356
10.1074/JBC.M010495200
P407
P577
2001-04-16T00:00:00Z