Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin
about
Gain-of-function mutations of ARHGAP31, a Cdc42/Rac1 GTPase regulator, cause syndromic cutis aplasia and limb anomaliesFunctional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine fingerCoordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylationRac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.Two novel CHN1 mutations in 2 families with Duane retraction syndromeLipid binding domains: more than simple lipid effectors.Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.Inhibition and termination of physiological responses by GTPase activating proteins.Beta2-chimaerin binds to EphA receptors and regulates cell migration.β3-chimaerin, a novel member of the chimaerin Rac-GAP family.Protein kinase C in cancer: The top five unanswered questions.Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance.Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndromeα2-Chimaerin regulates a key axon guidance transition during development of the oculomotor projection.Assessment of Jatropha curcas L. biodiesel seed cake toxicity using the zebrafish (Danio rerio) embryo toxicity (ZFET) test.
P2860
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P2860
Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of an autoinhib ...... f the Rac-GAP alpha2-chimaerin
@en
type
label
Identification of an autoinhib ...... f the Rac-GAP alpha2-chimaerin
@en
prefLabel
Identification of an autoinhib ...... f the Rac-GAP alpha2-chimaerin
@en
P2093
P2860
P356
P1476
Identification of an autoinhib ...... f the Rac-GAP alpha2-chimaerin
@en
P2093
Federico Coluccio Leskow
Francheska Colón-González
Marcelo G Kazanietz
P2860
P304
35247-35257
P356
10.1074/JBC.M806264200
P407
P577
2008-09-30T00:00:00Z