Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway.
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Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activationProtein-tyrosine-phosphatase-mediated epidermal growth factor (EGF) receptor transinactivation and EGF receptor-independent stimulation of mitogen-activated protein kinase by bradykinin in A431 cellsMu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytesS338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3Tyrosine kinase signalling in breast cancer. Epidermal growth factor receptor: convergence point for signal integration and diversificationRegulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinasesInsulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350Activation of the p38 and p42/p44 mitogen-activated protein kinase families by the histamine H(1) receptor in DDT(1)MF-2 cellsSrc-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptorSrc and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascadeCXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrityThe Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocationA Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase , and Protein Kinase CGi-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor ShcPhosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation.Phosphorylation of the G protein gamma12 subunit regulates effector specificity.Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway.N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.Acute opioid receptor desensitization and tolerance: is there a link?Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytesc-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survivalA function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells.Bradykinin B(2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation.Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell lineRas-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.Ammonium activates ouabain-activated signalling pathway in astrocytes: therapeutic potential of ouabain antagonist.Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors.Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinasebeta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways.Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: dissection of intracellular signaling pathwaysMechanisms of endothelin-1-induced MAP kinase activation in adrenal glomerulosa cells.Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and AktRole of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes.Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways.
P2860
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P2860
Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Phosphatidylinositol 3-kinase ...... tein kinase signaling pathway.
@en
type
label
Phosphatidylinositol 3-kinase ...... tein kinase signaling pathway.
@en
prefLabel
Phosphatidylinositol 3-kinase ...... tein kinase signaling pathway.
@en
P2093
P2860
P356
P1476
Phosphatidylinositol 3-kinase ...... tein kinase signaling pathway.
@en
P2093
L M Luttrell
R J Lefkowitz
T van Biesen
P2860
P304
12133-12136
P356
10.1074/JBC.271.21.12133
P407
P577
1996-05-01T00:00:00Z