S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
about
Raf family kinases: old dogs have learned new tricksRaf activation is regulated by tyrosine 510 phosphorylation in DrosophilaCalcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation.Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1B-Raf and Raf-1 are regulated by distinct autoregulatory mechanismsRegulation of Raf-1 activation and signalling by dephosphorylationAdhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylationInsulin enhances growth hormone induction of the MEK/ERK signaling pathwayThe RAF proteins take centre stageMEK1 activation by PAK: a novel mechanism.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysCNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation.Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling.p21 activated kinase 5 activates Raf-1 and targets it to mitochondriaTargeting prostate cancer based on signal transduction and cell cycle pathways.PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by ErkAICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascadeMechanistic principles of RAF kinase signaling.Allosteric activation of functionally asymmetric RAF kinase dimers.Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells.Characterization of Ser338 phosphorylation for Raf-1 activationRaf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K.Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.Apigenin and LY294002 prolong EGF-stimulated ERK1/2 activation in PC12 cells but are unable to induce full differentiation.Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.The requirement of specific membrane domains for Raf-1 phosphorylation and activation.Serine 338 phosphorylation is dispensable for activation of c-Raf1.PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway.
P2860
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P2860
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@ast
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@en
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@nl
type
label
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@ast
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@en
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@nl
prefLabel
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@ast
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@en
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@nl
P2860
P3181
P1476
S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3
@en
P2093
A Chiloeches
P2860
P304
P3181
P356
10.1128/MCB.21.7.2423-2434.2001
P407
P577
2001-04-01T00:00:00Z