Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
about
Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Resolution of single and double Holliday junction recombination intermediates by GEN1.Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.Holliday junction-resolving enzymes-structures and mechanisms.Resolvase OsGEN1 Mediates DNA Repair by Homologous Recombination.Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1
P2860
Q33701418-647A603C-9B62-44D5-B4E4-C9D86FAEBCC4Q33851243-5904C705-EA99-43CA-B566-AC19B5A3DA5FQ37599023-BE442B68-71EE-4D97-99DF-CE90CB69DBFEQ37712232-B579D45D-DC54-4BDC-A6B7-EF68B938E0E4Q39042932-4C00DD7A-E28B-4E8F-AE97-DA6BD1BB1545Q48098663-16473862-674F-424D-A558-D43D087BC7B6Q52326200-F275AFAD-C118-4EBB-83BB-2087E59B1570Q55368890-CD73DFA2-CE68-4216-BCC3-8B2C3194F703Q59125485-B90B3DCD-5CD2-4A6A-8CB3-356BF8794E77
P2860
Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Human Holliday junction resolv ...... DNA recognition and cleavage.
@en
type
label
Human Holliday junction resolv ...... DNA recognition and cleavage.
@en
prefLabel
Human Holliday junction resolv ...... DNA recognition and cleavage.
@en
P2093
P2860
P356
P1433
P1476
Human Holliday junction resolv ...... DNA recognition and cleavage.
@en
P2093
Boris Pfander
Lissa Nicola Princz
Maren Felizitas Klügel
Shun-Hsiao Lee
P2860
P356
10.7554/ELIFE.12256
P407
P577
2015-12-18T00:00:00Z