about
Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overloadExercise training reduces resting heart rate via downregulation of the funny channel HCN4Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes.Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice.Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.The cardiovascular phenotype of a mouse model of acromegaly.
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P50
description
researcher
@en
wetenschapper
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հետազոտող
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name
Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Prehar S
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prefLabel
Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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Sukhpal Prehar
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P106
P1153
6507949223
P31
P496
0000-0002-4334-7931