Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
about
Terminal sialylation is altered in airway cells with impaired CFTR-mediated chloride transport.Novel pharmacologic therapies for cystic fibrosisPhosphorylation of CFTR by PKA promotes binding of the regulatory domainRectification of cystic fibrosis transmembrane conductance regulator chloride channel mediated by extracellular divalent cations.Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes.Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openingsIncomplete distal renal tubular acidosis from a heterozygous mutation of the V-ATPase B1 subunit.A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solutionActivation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification.Cystic fibrosis transmembrane conductance regulator-dependent regulation of epithelial inducible nitric oxide synthase expression.A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules.Functional dissection of the R domain of cystic fibrosis transmembrane conductance regulator.A conserved region of the R domain of cystic fibrosis transmembrane conductance regulator is important in processing and function.Overproduction of the CFTR R domain leads to increased levels of asialoGM1 and increased Pseudomonas aeruginosa binding by epithelial cells.Direct activation of cystic fibrosis transmembrane conductance regulator channels by 8-cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-diallyl-8-cyclohexylxanthine (DAX).Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel.ATP depletion induces a loss of respiratory epithelium functional integrity and down-regulates CFTR (cystic fibrosis transmembrane conductance regulator) expression.P-glycoprotein is not a swelling-activated Cl- channel; possible role as a Cl- channel regulator.Cystic fibrosis transmembrane conductance regulator. Permeant ions find the pore.NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.Phosphorylation-induced conformational changes of cystic fibrosis transmembrane conductance regulator monitored by attenuated total reflection-Fourier transform IR spectroscopy and fluorescence spectroscopy.Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.Stimulation of CFTR activity by its phosphorylated R domain.
P2860
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P2860
Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Phosphorylation-dependent bloc ...... by exogenous R domain protein.
@en
type
label
Phosphorylation-dependent bloc ...... by exogenous R domain protein.
@en
prefLabel
Phosphorylation-dependent bloc ...... by exogenous R domain protein.
@en
P2093
P2860
P921
P356
P1476
Phosphorylation-dependent bloc ...... by exogenous R domain protein.
@en
P2093
P2860
P304
P356
10.1074/JBC.271.13.7351
P407
P577
1996-03-01T00:00:00Z