Stimulation of CFTR activity by its phosphorylated R domain.
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The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesisThe ABC protein turned chloride channel whose failure causes cystic fibrosisStructure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulatorCFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisRegulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cellsLung infections associated with cystic fibrosis.Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.Domain-domain associations in cystic fibrosis transmembrane conductance regulator.Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain.Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter.Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.Phosphorylation of CFTR by PKA promotes binding of the regulatory domainCFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivoContribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openingsA macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKAA conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulatorRegulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Molecular modelling and molecular dynamics of CFTR.Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanismInsight in eukaryotic ABC transporter function by mutation analysis.Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domainsDistinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solutionHow Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).Cooperative assembly and misfolding of CFTR domains in vivo.Molecular bases of impaired water and ion movements in inflammatory bowel diseases.Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.CFTR regulatory region interacts with NBD1 predominantly via multiple transient helicesNucleotide-binding domain 1 of cystic fibrosis transmembrane conductance regulator production of a suitable protein for structural studies.Identification of the cystic fibrosis transmembrane conductance regulator domains that are important for interactions with ROMK2.Expression and purification of the first nucleotide-binding domain and linker region of human multidrug resistance gene product: comparison of fusions to glutathione S-transferase, thioredoxin and maltose-binding protein.Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.
P2860
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P2860
Stimulation of CFTR activity by its phosphorylated R domain.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Stimulation of CFTR activity by its phosphorylated R domain.
@en
Stimulation of CFTR activity by its phosphorylated R domain.
@nl
type
label
Stimulation of CFTR activity by its phosphorylated R domain.
@en
Stimulation of CFTR activity by its phosphorylated R domain.
@nl
prefLabel
Stimulation of CFTR activity by its phosphorylated R domain.
@en
Stimulation of CFTR activity by its phosphorylated R domain.
@nl
P2860
P356
P1433
P1476
Stimulation of CFTR activity by its phosphorylated R domain.
@en
P2093
P2860
P2888
P304
P356
10.1038/38514
P407
P577
1997-09-01T00:00:00Z
P6179
1050428646