Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
about
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesDevelopment, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transportersThe multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity.Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds.Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.Molecular analysis of the multidrug transporter, P-glycoprotein.Synergistic effects of A-B-C-type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma.Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistanceAlterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.Renal Drug Transporters and Drug Interactions.Optimizing chemotherapy by measuring reversal of P-glycoprotein activity in plasma membrane vesicles.Structural recognition of tubulysin B derivatives by multidrug resistance efflux transporters in human cancer cells.Mitochondrial P-glycoprotein ATPase contributes to insecticide resistance in the cotton bollworm, Helicoverpa armigera (Noctuidae: Lepidoptera).Modulation of P-glycoprotein ATPase of Helicoverpa armigera by cholesterol: effects on ATPase activity and interaction of insecticides.Stimulatory effect of insecticides on partially purified P-glycoprotein ATPase from the resistant pest Helicoverpa armigera.Phosphorylation site mutations in the human multidrug transporter modulate its drug-stimulated ATPase activity.Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Transition state analysis of the coupling of drug transport to ATP hydrolysis by P-glycoprotein.Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents.Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells.Many P-glycoprotein substrates do not inhibit the transport process across cell membranes.Quantitative characterization of direct P-glycoprotein inhibition by St John's wort constituents hypericin and hyperforin.Quantitative evaluation of isothiocyanates as substrates and inhibitors of P-glycoprotein.Inhibition of P-glycoprotein by two artemisinin derivatives.Measuring the internal concentration of volatile organic compounds in small organisms using micro-QuEChERS coupled to LVI-GC-MS/MS.Classification analysis of P-glycoprotein substrate specificity.LysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance.Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells.Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein.ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?
P2860
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P2860
Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Competition of hydrophobic pep ...... vealed by its ATPase activity.
@en
type
label
Competition of hydrophobic pep ...... vealed by its ATPase activity.
@en
prefLabel
Competition of hydrophobic pep ...... vealed by its ATPase activity.
@en
P2093
P356
P1476
Competition of hydrophobic pep ...... vealed by its ATPase activity.
@en
P2093
P304
P356
10.1074/JBC.271.6.3163
P407
P577
1996-02-01T00:00:00Z