about
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimerMRP3, an organic anion transporter able to transport anti-cancer drugsFlexibility in the ABC transporter MsbA: Alternating access with a twist.Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugsWhere is it and How Does it Get There - Intracellular Localization and Traffic of P-glycoproteinStructure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pumpThe crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporterStructural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacRATP-binding cassette B1 gene polymorphisms, mRNA expression and chemosensitivity to paclitaxel in non-small cell lung cancer cells.P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cellsAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionSaint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposureFunctional analysis of novel multidrug transporters from human pathogensXenobiotic efflux in bacteria and fungi: a genomics updateDoxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cellsSelection of pancreatic cancer cell-binding landscape phages and their use in development of anticancer nanomedicines.Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.P-glycoprotein and drug therapy in organ transplantation.Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma.The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding.ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.Interaction of common azole antifungals with P glycoproteinRegulation of bacterial drug export systemsPharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation.Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.Polymorphisms in the ABC drug transporter gene MDR1.A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrEApoptotic sphingolipid ceramide in cancer therapy.Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivoTransporters/receptors in the anterior chamber: pathways to explore ocular drug delivery strategies.PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs.Structure and function of efflux pumps that confer resistance to drugsA serum protein profile predictive of the resistance to neoadjuvant chemotherapy in advanced breast cancers.PET imaging of multidrug resistance in tumors using 18F-fluoropaclitaxel.Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance.
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
P-glycoprotein and multidrug resistance.
@en
type
label
P-glycoprotein and multidrug resistance.
@en
prefLabel
P-glycoprotein and multidrug resistance.
@en
P2093
P1476
P-glycoprotein and multidrug resistance.
@en
P2093
Ambudkar SV
Gottesman MM
P304
P356
10.1016/S0959-437X(96)80091-8
P577
1996-10-01T00:00:00Z