Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition
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Two heads are better than one: crystal structure of the insect derived double domain Kazal inhibitor rhodniin in complex with thrombinCrystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitorThe crystal structure of α-thrombin-hirunorm IV complex reveals a novel specificity site recognition modeCrystal Structure of a Biosynthetic Sulfo-hirudin Complexed to ThrombinThe Tick-Derived Anticoagulant Madanin Is Processed by Thrombin and Factor XaThe ornithodorin-thrombin crystal structure, a key to the TAP enigma?Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bugThrombin-specific inhibition by and slow cleavage of hirulog-1Proton bridging in the interactions of thrombin with hirudin and its mimics.Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site.Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.The many faces of protease-protein inhibitor interactionFree Fatty Acids Modulate Thrombin Mediated Fibrin Generation Resulting in Less Stable Clots.Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombinThe co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand bindingHirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complexCrystal structure of the complex between thrombin and the central "E" region of fibrin.Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin.High-affinity RNA ligands to human alpha-thrombin.Thrombin and antithrombotic therapy in interventional cardiology.The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution.Contribution of interactions with the core domain of hirudin to the stability of its complex with thrombin.Catabolism of hirudin and thrombin-hirudin complexes in the rat.Evidence for common structural changes in thrombin induced by active-site or exosite bindingCrystallization and preliminary crystallographic characterization of three peptidic inhibitors in complex with α-thrombin.Crystallization and preliminary X-ray diffraction analysis of a protease inhibitor from the haemolymph of the Indian tasar silkworm Antheraea mylitta.Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin.Oxidative folding of hirudin in human serum.Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.Ionic interactions in the formation of the thrombin-hirudin complex.Cleavage of the thrombin receptor: identification of potential activators and inactivators.Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib.
P2860
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P2860
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition
description
1990 nî lūn-bûn
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1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
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1990年学术文章
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1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
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1990年學術文章
@zh-hant
name
Crystal structure of the throm ...... of serine protease inhibition
@en
type
label
Crystal structure of the throm ...... of serine protease inhibition
@en
prefLabel
Crystal structure of the throm ...... of serine protease inhibition
@en
P2093
P2860
P1433
P1476
Crystal structure of the throm ...... of serine protease inhibition
@en
P2093
Grossenbacher H
Grütter MG
Hofsteenge J
Priestle JP
P2860
P304
P407
P577
1990-08-01T00:00:00Z