The biochemical basis for stereochemical control in polyketide biosynthesis.
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Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryStructural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-AlkeneDivergence of multimodular polyketide synthases revealed by a didomain structureStructure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide SynthaseA labile point in mutant amphotericin polyketide synthasesElucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchangeSBSPKS: structure based sequence analysis of polyketide synthasesProgramming of erythromycin biosynthesis by a modular polyketide synthasePolyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthaseEpigenetic genome mining of an endophytic fungus leads to the pleiotropic biosynthesis of natural productsReprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.Structural analysis of protein-protein interactions in type I polyketide synthasesCoupled methyl group epimerization and reduction by polyketide synthase ketoreductase domains. Ketoreductase-catalyzed equilibrium isotope exchange.Polyketide stereocontrol: a study in chemical biology.Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry.The structures of type I polyketide synthases.Dissecting complex polyketide biosynthesis.Assembly line polyketide synthases: mechanistic insights and unsolved problems.Stereocontrol within polyketide assembly lines.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Polyene macrolide biosynthesis in streptomycetes and related bacteria: recent advances from genome sequencing and experimental studies.Navigating the fungal polyketide chemical space: from genes to molecules.A fungal ketoreductase domain that displays substrate-dependent stereospecificity.Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.A trans-acting ketoreductase in biosynthesis of a symmetric polyketide dimer SIA7248.Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.Configurational assignment of secondary hydroxyl groups and methyl branches in polyketide natural products through bioinformatic analysis of the ketoreductase domain.Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.Engineered polyketides: Synergy between protein and host level engineering.Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products.Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
P2860
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P2860
The biochemical basis for stereochemical control in polyketide biosynthesis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The biochemical basis for stereochemical control in polyketide biosynthesis.
@en
type
label
The biochemical basis for stereochemical control in polyketide biosynthesis.
@en
prefLabel
The biochemical basis for stereochemical control in polyketide biosynthesis.
@en
P2093
P2860
P356
P1476
The biochemical basis for stereochemical control in polyketide biosynthesis.
@en
P2093
Alice Y Chen
Chaitan Khosla
Chiara R Valenzano
David E Cane
Rachel J Lawson
P2860
P304
18501-18511
P356
10.1021/JA908296M
P407
P577
2009-12-01T00:00:00Z