Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor.
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The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membraneRNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activityThe second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domainMolecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequenceA dopamine D2 receptor mutant capable of G protein-mediated signaling but deficient in arrestin bindingMutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activityEvolution of vertebrate GnRH receptors from the perspective of a Basal vertebrateSingle amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis.cDNA cloning and characterization of guinea-pig leukotriene B4 receptorA chicken gonadotropin-releasing hormone receptor that confers agonist activity to mammalian antagonists. Identification of D-Lys(6) in the ligand and extracellular loop two of the receptor as determinants.Internalization rates of murine and ovine gonadotropin-releasing hormone receptors.A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors.Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i)Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expressionIdentification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2.Molecular cloning and pharmacological characterization of two novel GnRH receptors in the lamprey (Petromyzon marinus).Role of the highly conserved Asp-Arg-Tyr motif in signal transduction of the CB2 cannabinoid receptor.Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling.Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.A role of Histidine151 in the lamprey gonadotropin-releasing hormone receptor-1 (lGnRHR-1): Functional insight of diverse amino acid residues in the position of Tyr of the DRY motif in GnRHR from an ancestral type II receptor.Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms.Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif.Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization.Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin-dependent pathway for internalization.Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins.Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitization.Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells.Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization.Self-compatible B mutants in coprinus with altered pheromone-receptor specificities.Cloning, tissue distribution, and central expression of the gonadotropin-releasing hormone receptor in the rainbow trout (Oncorhynchus mykiss).Ligand-induced internalization of cholecystokinin receptors. Demonstration of the importance of the carboxyl terminus for ligand-induced internalization of the rat cholecystokinin type B receptor but not the type A receptor.RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein.Differences in conformational properties of the second intracellular loop (IL2) in 5HT(2C) receptors modified by RNA editing can account for G protein coupling efficiency.Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling.Requirement of membrane-proximal amino acids in the carboxyl-terminal tail for expression of the rat AT1a angiotensin receptor.Serotonin 1A receptor (5-HT1A) of the sea lamprey: cDNA cloning and expression in the central nervous system.Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq.
P2860
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P2860
Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Effects of second intracellula ...... in-releasing hormone receptor.
@en
type
label
Effects of second intracellula ...... in-releasing hormone receptor.
@en
prefLabel
Effects of second intracellula ...... in-releasing hormone receptor.
@en
P2093
P2860
P356
P1476
Effects of second intracellula ...... in-releasing hormone receptor.
@en
P2093
P2860
P304
22820-22826
P356
10.1074/JBC.270.39.22820
P407
P577
1995-09-01T00:00:00Z