Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors.
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Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivoPrecursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATPProgastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem CellsBinding sites for progastrin-derived peptides in colonic crypts.Molecular cloning and sequence of the ovine gastrin gene.Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells.Topical review. Gastrin and gastric epithelial physiology.Lessons from genetically engineered animal models. III. Lessons learned from gastrin gene deletion in mice.Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.Gastrin exerts pleiotropic effects on human melanoma cell biology.Cytotoxic agents directed to peptide hormone receptors: defining the requirements for a successful drug.Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.Role of gastrin-peptides in Barrett's and colorectal carcinogenesis.Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosaProcessing and proliferative effects of human progastrin in transgenic mice.The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.Paradoxically augmented anti-tumorigenic action of proton pump inhibitor and GastrininAPCMin/+ intestinal polyposis model.The structure of bioactive analogs of the N-terminal region of gastrin-17.Bioactivity of analogs of the N-terminal region of gastrin-17.Use of interfering RNA to investigate the role of endogenous gastrin in the survival of gastrointestinal cancer cells.Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.Glycine-extended gastrin regulates HEK cell growth.Gastrin, gastrin receptors and colorectal carcinoma.Proliferative effects of cholecystokinin in GH3 pituitary cells mediated by CCK2 receptors and potentiated by insulin.Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis.Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.Antiproliferative effect of a novel cholecystokinin-B/gastrin receptor antagonist, YM022.Cholecystokinin receptor antagonist alters pancreatic cancer microenvironment and increases efficacy of immune checkpoint antibody therapy in mice.Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites.Regulation by gastric acid of the processing of progastrin-derived peptides in rat antral mucosa
P2860
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P2860
Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Novel gastrin receptors mediat ...... n (CCK)-A and CCK-B receptors.
@en
type
label
Novel gastrin receptors mediat ...... n (CCK)-A and CCK-B receptors.
@en
prefLabel
Novel gastrin receptors mediat ...... n (CCK)-A and CCK-B receptors.
@en
P2093
P2860
P356
P1476
Novel gastrin receptors mediat ...... n (CCK)-A and CCK-B receptors.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.15.8429
P407
P577
1995-04-01T00:00:00Z