Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
about
Characterization of new substrates targeted by Yersinia tyrosine phosphatase YopHStructure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseasesYersinia type III effectors perturb host innate immune responsesEffector triggered manipulation of host immune response elicited by different pathotypes of Escherichia coliCytotoxic necrotizing factor-Y boosts Yersinia effector translocation by activating Rac protein.Role of IFN-gamma and IL-6 in a protective immune response to Yersinia enterocolitica in mice.NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH.In vitro membrane reconstitution of the T-cell receptor proximal signaling network.Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signalingThe minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.Tipping the balance by manipulating post-translational modifications.The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches.Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase.ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lckInhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activationHigh-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.Pathogenesis of Y. enterocolitica and Y. pseudotuberculosis in Human Yersiniosis.Disabling surveillance: bacterial type III secretion system effectors that suppress innate immunity.Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.The bacterial injection kit: type III secretion systems.Role of protein phosphorylation on serine/threonine and tyrosine in the virulence of bacterial pathogens.Targeting the PTPome in human disease.The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.Interaction between Yersinia pestis and the host immune systemBurkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin.Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosisCbl enforces an SLP76-dependent signaling pathway for T cell differentiationIdentifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infectionPhosphoproteomics in bacteria: towards a systemic understanding of bacterial phosphorylation networks.Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model.Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections.Yersinia enterocolitica YopH-Deficient Strain Activates Neutrophil Recruitment to Peyer's Patches and Promotes Clearance of the Virulent Strain.Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse infection model.Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host.Infection Strategies of Bacterial and Viral Pathogens through Pathogen-Human Protein-Protein InteractionsImmunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike.Yersinia pestis and host macrophages: immunodeficiency of mouse macrophages induced by YscW.
P2860
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P2860
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Lck dephosphorylation at Tyr-3 ...... by Yersinia phosphatase YopH.
@en
type
label
Lck dephosphorylation at Tyr-3 ...... by Yersinia phosphatase YopH.
@en
prefLabel
Lck dephosphorylation at Tyr-3 ...... by Yersinia phosphatase YopH.
@en
P2093
P2860
P356
P1476
Lck dephosphorylation at Tyr-3 ...... by Yersinia phosphatase YopH.
@en
P2093
Andres Alonso
Nunzio Bottini
Scott Williams
Shane Bruckner
Souad Rahmouni
Tomas Mustelin
P2860
P304
P356
10.1074/JBC.M308978200
P407
P577
2003-11-17T00:00:00Z