Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation - Wikidata - awgldk - TriplyDB

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

http://www.wikidata.org/entity/Q41491447

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International physician survey on management of FOP: a modified Delphi study.TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.Fibrodysplasia ossificans progressiva: a case report.Drug therapy targeting pyrophosphate slows the ossification of spinal ligaments in twy mice.Fibrodysplasia ossificans progressiva: Basic understanding and experimental models.Hard targets for a second skeleton: therapeutic horizons for fibrodysplasia ossificans progressiva (FOP).Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses.Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat-related heterotopic ossification.Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.Animal models of fibrodysplasia ossificans progressiva.Stem cells and heterotopic ossification: Lessons from animal models.The Horizon of a Therapy for Rare Genetic Diseases: A "Druggable" Future for Fibrodysplasia Ossificans Progressiva.Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities.Emerging targeted drug therapies in skeletal dysplasias.An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva Recent Topics in Fibrodysplasia Ossificans Progressiva Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

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P2860

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

http://www.wikidata.org/entity/Q41491447

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Palovarotene Inhibits Heteroto ...... ans Progressiva (FOP) Mutation

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Palovarotene Inhibits Heteroto ...... ans Progressiva (FOP) Mutation

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Palovarotene Inhibits Heteroto ...... ans Progressiva (FOP) Mutation

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Journal of Bone and Mineral Research

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Palovarotene Inhibits Heteroto ...... ans Progressiva (FOP) Mutation

@en

P2093

Deyu Zhang

http://www.w3.org/2001/XMLSchema#string

Eileen M Shore

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Frederick S Kaplan

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Kenta Uchibe

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Masahiro Iwamoto

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Maurizio Pacifici

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Michael R Convente

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Salin A Chakkalakal

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P2860

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

Mechanisms of retinoic acid signalling and its roles in organ and limb development

ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma

Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse

Developmental regulation of the growth plate

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1

ACVR1 p.Q207E causes classic fibrodysplasia ossificans progressiva and is functionally distinct from the engineered constitutively active ACVR1 p.Q207D variant

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1666-1675

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scholarly article

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10.1002/JBMR.2820

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9

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31

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Aris Economides

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2016-02-20T00:00:00Z

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26896819

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fibrodysplasia ossificans progressiva

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4992469

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