In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
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Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonistsTachykinin NK1 and NK2 receptors mediate inhibitory vs excitatory motor responses in human isolated corpus cavernosum and spongiosumPharmacological profile of the novel mammalian tachykinin, hemokinin 1Characterization of the endokinins: human tachykinins with cardiovascular activityAssociation between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venulesSubstance P selectively decreases paired pulse depression in the rat hippocampal slice.Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel diseaseNeural mechanisms underlying migrating motor complex formation in mouse isolated colonThe role of sensory nerve endings in nerve growth factor-induced airway hyperresponsiveness to histamine in guinea-pigsActivation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repairThe role of sensory neuropeptides and nitric oxide on pulpal blood flow and tissue pressure in the ferret.Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO.Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear.Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo.Species differences in the actions of sensory neuropeptides on contractility of the smooth muscle of the rat and guinea-pig prostate.Effects of tachykinins on uterine smooth muscle.Effects of tachykinin receptor agonists and antagonists on the guinea-pig isolated oesophagus.Autocrine regulation of human sperm motility by tachykinins.Expression and function of human hemokinin-1 in human and guinea pig airwaysModulatory effect of neuropeptide Y on acetylcholine-induced oedema and vasoconstriction in isolated perfused lungs of rabbitDecreased vascular permeability response to substance P in airways of genetically hypertensive rats.Neurokinin B- and specific tachykinin NK(3) receptor agonists-induced airway hyperresponsiveness in the guinea-pigSubstance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and miceFunctional characterization of tachykinin NK1 receptors in the mouse uterusInvolvement of tachykinin receptors in sensitisation to cow's milk proteins in guinea pigs.Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.Pharmacological evidence supporting a role for IL-1, IL-2 and serotonin in the inflammation induced by Schistosoma mansoni soluble egg antigen (SEA) in rat pawsRole of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in ratsActivation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea-pig.Evidence for the participation of glutamate in reflexes involving afferent, substance P-containing nerve fibres in the ratTachykinin inhibition of acid-induced gastric hyperaemia in the rat.A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivoPrenatal nicotinic exposure upregulates pulmonary C-fiber NK1R expression to prolong pulmonary C-fiber-mediated apneic response.Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2Evidence that tachykinin NK2 receptors modulate resting tone in the rat isolated small intestine.Role of NK1 and NK2 receptors in mouse gastric mechanical activity.Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.A study of neurokinins and other oedema-inducing mediators and mechanisms in thermal injury.Recent developments in tachykinin NK1 receptor antagonists: prospects for the treatment of migraine headache.
P2860
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P2860
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
In vitro and in vivo biologica ...... kinin NK1 receptor antagonist.
@en
type
label
In vitro and in vivo biologica ...... kinin NK1 receptor antagonist.
@en
prefLabel
In vitro and in vivo biologica ...... kinin NK1 receptor antagonist.
@en
P2093
P1476
In vitro and in vivo biologica ...... kinin NK1 receptor antagonist.
@en
P2093
Doutremepuich JD
Emonds-Alt X
Proietto V
Santucci V
Steinberg R
P304
P356
10.1016/0014-2999(93)90027-F
P407
P577
1993-12-01T00:00:00Z