about
Thermal difference spectra: a specific signature for nucleic acid structures.Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystalSequence- and structural-selective nucleic acid binding revealed by the melting of mixtures.Structure of a DNA-bisdaunomycin complexSynthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I InhibitorsInteraction of an acridine dimer with DNA quadruplex structures.Discovery of novel triple helical DNA intercalators by an integrated virtual and actual screening platform.Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescenceCalories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition.A Discovery Funnel for Nucleic Acid Binding Drug CandidatesLinkage of cation binding and folding in human telomeric quadruplex DNA.Clinical application of plasma thermograms. Utility, practical approaches and considerations.An improved model for the hTERT promoter quadruplexA multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia.G-quadruplex structure and stability illuminated by 2-aminopurine phasor plotsAnalysis of multidimensional G-quadruplex melting curvesIsothermal folding of G-quadruplexes.Competition dialysis: an assay to measure the structural selectivity of drug-nucleic acid interactions.Calorimetry outside the box: a new window into the plasma proteome.Modeling complex equilibria in isothermal titration calorimetry experiments: thermodynamic parameters estimation for a three-binding-site modelCriteria for the mode of binding of DNA binding agents.Kinetics and mechanism of K+- and Na+-induced folding of models of human telomeric DNA into G-quadruplex structures.A new bisintercalating anthracycline with picomolar DNA binding affinity.Stability and kinetics of G-quadruplex structuresCalorimetric analysis of the plasma proteomeHydration of drug-DNA complexes: greater water uptake for adriamycin compared to daunomycinEnergetics and kinetics of a conformational switch in G-quadruplex DNADetection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry.Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability.Polymorphism and resolution of oncogene promoter quadruplex-forming sequences.Folding and unfolding pathways of the human telomeric G-quadruplex.Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis.Biophysical chemistry of the daunomycin-DNA interaction.Thermodynamic studies for drug design and screening.Parsing free energies of drug-DNA interactions.Binding of netropsin to several DNA constructs: evidence for at least two different 1:1 complexes formed from an -AATT-containing ds-DNA construct and a single minor groove binding ligand.Drug--DNA interactions.Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure.Unraveling the Thermodynamics of the Folding and Interconversion of Human Telomere G-Quadruplexes.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Jonathan B. Chaires
@ast
Jonathan B. Chaires
@en
Jonathan B. Chaires
@es
Jonathan B. Chaires
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type
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Jonathan B. Chaires
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Jonathan B. Chaires
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Jonathan B. Chaires
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Jonathan B. Chaires
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prefLabel
Jonathan B. Chaires
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Jonathan B. Chaires
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Jonathan B. Chaires
@es
Jonathan B. Chaires
@sl
P106
P1153
7006806705
P21
P31
P496
0000-0001-5477-945X