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Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationComparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype SelectivityIntrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIIIType 1 and Type 2 scenarios in hydrogen exchange mass spectrometry studies on protein-ligand complexes.Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.Effect of G-quadruplex polymorphism on the recognition of telomeric DNA by a metal complex.Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzymeIdentification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.Modeling complex equilibria in isothermal titration calorimetry experiments: thermodynamic parameters estimation for a three-binding-site modelNucleotide-binding mechanisms in pseudokinases.Molecular docking for drug discovery and development: a widely used approach but far from perfect.Applications of isothermal titration calorimetry - the research and technical developments from 2011 to 2015.Differential scanning calorimetry and fluorimetry measurements of monoclonal antibodies and reference proteins: Effect of scanning rate and dye selection.A look at ligand binding thermodynamics in drug discovery.Rapid characterization of folding and binding interactions with thermolabile ligands by DSC.Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method.Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones.Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex.Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions.Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions.Multifaceted Studies of the DNA Interactions and In Vitro Cytotoxicity of Anticancer Polyaromatic Platinum(II) Complexes.Molecular Recognition of Azelaic Acid and Related Molecules with DNA Polymerase I Investigated by Molecular Modeling Calculations.Superheated droplets for protein thermal stability analyses of GFP, BSA and Taq-polymerase
P2860
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P2860
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Thermodynamic studies for drug design and screening.
@en
Thermodynamic studies for drug design and screening.
@nl
type
label
Thermodynamic studies for drug design and screening.
@en
Thermodynamic studies for drug design and screening.
@nl
prefLabel
Thermodynamic studies for drug design and screening.
@en
Thermodynamic studies for drug design and screening.
@nl
P2860
P1476
Thermodynamic studies for drug design and screening.
@en
P2093
Nichola C Garbett
P2860
P304
P356
10.1517/17460441.2012.666235
P407
P577
2012-03-08T00:00:00Z