Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.
about
X-ray structure of dopamine transporter elucidates antidepressant mechanismInsights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDATTargeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesStructural basis for action by diverse antidepressants on biogenic amine transportersRepeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanismsSerotonergic modulation of conditioned fear.Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters.GATMD: γ-aminobutyric acid transporter mutagenesis database.X-ray structures and mechanism of the human serotonin transporter.The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transportersMutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters.Unifying concept of serotonin transporter-associated currentsMonoamine transporters: vulnerable and vital doorkeepers.Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.The Environment Shapes the Inner Vestibule of LeuT.Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.Chloride binding site of neurotransmitter sodium symporters.Comparison of female Fischer and Sprague-Dawley rats in the response to ketanserin.Identification of novel serotonin transporter compounds by virtual screening.Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.Structural perspectives on secondary active transporters.Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer.Comparative modeling of the human monoamine transporters: similarities in substrate binding.Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket.A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin.Cholesterol binding to a conserved site modulates conformation, pharmacology and transport kinetics of the human serotonin transporter.Identification of the inhibitory mechanism of FDA approved selective serotonin reuptake inhibitors: an insight from molecular dynamics simulation study.Imaging genetics: implications for research on variable antidepressant drug response.Structural basis for recognition of diverse antidepressants by the human serotonin transporter.
P2860
Q24612997-CAB788B1-F08A-4FC0-994C-8752BB5E9447Q26781554-14233150-C5E9-4123-99E7-B1E2FFA13DE1Q27023257-4949C34E-9B4D-48A0-8E2B-D280A5E27508Q27680298-819C1E7F-2F88-44A4-AEBD-DABEB05BBAC2Q30379362-D5107EC8-5F82-4FBC-B937-88A9093642A4Q30446862-33E438EE-7A00-4B88-8CC0-194BDBD0DFDEQ33604840-7F5B5BA8-1E0A-4D83-9AFF-F6515BDB542AQ34064167-021D5F4C-0FCE-49B1-9CB9-D07E4D9FBBFDQ34103328-3A9E8FAB-CA72-4358-9CDF-C409347A6351Q34137102-15DF13BF-6BE6-4002-BE7F-C4228C6B3A0FQ34152288-EEEF37D6-1F83-4FB1-BA05-66B2173D3BC6Q34161514-6769F850-F113-4337-B750-DD419A4A3833Q34383067-B80915EF-21C6-4194-B610-4E31D532484FQ34521033-7FA2A381-30C5-40C3-BF77-5437ECB4E7B1Q34660686-701A43E7-D8DC-4ACC-AB99-CAB1FAC5679CQ35011459-7858CC4A-E42B-4E63-9F68-FAAB3518BF1DQ35016767-EC8B90AF-1492-43E8-B750-668312FE4FFAQ35123142-1E3B6D99-C0FD-4D87-9055-25D73A1AACA8Q35643721-36BD86E4-2FF2-43BE-8610-E9449973374DQ35877150-8DDE6BF8-B1F8-4F2F-BFFE-69D810E3A39BQ35975646-D737F2D6-B04E-4BA3-8317-94A4174E6DB8Q36189760-63E99329-B9DD-4BBF-96A5-1CE99B144BAFQ36754967-59A00277-8E90-497D-9D6F-35B6509B3F73Q36884270-90720D29-5CF5-47FC-89AD-C5EAED6F44D1Q37515934-1D77CE36-4FC9-4962-A1C2-CE5550F4FF14Q37695877-237C3D80-57CA-4A5F-8904-3D5DB8380079Q37720119-D44BFC25-05A3-4095-8C4D-349C330D734AQ37775229-C0EEEBE7-68FE-4C50-A33E-D4A9039EE68AQ38949208-A48DD163-E40C-4D47-BEE8-919E08E187AEQ39192034-A16E9D31-D547-413D-AEB9-D13AF8F577B8Q42425044-631B0186-CE5F-46E4-93B4-CFEB9C53C6C1Q43195423-59793C48-B76A-436E-BD29-F0CDEFE3FE69Q47651388-374A03B7-927D-4F52-B5AB-D0EC73C9B5ACQ48066819-040800DF-2D87-4822-8C39-83E37774B04BQ48148747-2E948478-3D9F-4CED-A86C-FE700632B0CDQ49594975-53BE3D3F-3D45-4FE3-B4C2-0C59C7F3D9DE
P2860
Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Fluoxetine (Prozac) binding to ...... de and conformational changes.
@en
type
label
Fluoxetine (Prozac) binding to ...... de and conformational changes.
@en
prefLabel
Fluoxetine (Prozac) binding to ...... de and conformational changes.
@en
P2093
P2860
P1476
Fluoxetine (Prozac) binding to ...... de and conformational changes.
@en
P2093
Gary Rudnick
Lucy R Forrest
Sotiria Tavoulari
P2860
P304
P356
10.1523/JNEUROSCI.0440-09.2009
P407
P577
2009-07-01T00:00:00Z