CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
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Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3ADevelopment of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strainsReliability and extension of quantitative prediction of CYP3A4-mediated drug interactions based on clinical dataDatabase analyses for the prediction of in vivo drug-drug interactions from in vitro data.Predicting in vivo drug interactions from in vitro drug discovery data.Characterization of xylazine metabolism in rat liver microsomes using liquid chromatography-hybrid triple quadrupole-linear ion trap-mass spectrometry.Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.Fluorometric evaluation of CYP3A4 expression using improved transgenic HepaRG cells carrying a dual-colour reporter for CYP3A4 and CYP3A7.Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening dataThe human CYP3A subfamily: practical considerations.Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipinePharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment.Assessment of drug-drug interactions: concepts and approaches.Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs.BJCP 40th anniversary: moving forward, looking back.Baseline lipophilicity relationships in human cytochromes P450 associated with drug metabolism.Rapid and quantitative measurement of metabolic stability without chromatography or mass spectrometryA Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteersAn evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid.Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.Impact of organic solvents on cytochrome P450 probe reactions: filling the gap with (S)-Warfarin and midazolam hydroxylationLuminogenic cytochrome P450 assays.In vitro approaches to investigate mechanism-based inactivation of CYP enzymes.Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in RatsPrincipal component analysis of CYP2C9 and CYP3A4 probe substrate/inhibitor panels.Drugs as CYP3A probes, inducers, and inhibitors.Predicting drug-drug interactions: an FDA perspectiveIn vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether.Cooperative properties of cytochromes P450.Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone.Contribution of baicalin on the plasma protein binding displacement and CYP3A activity inhibition to the pharmacokinetic changes of nifedipine in rats in vivo and in vitro.The missing linkage: what pharmacogenetic associations are left to find in CYP3A?Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro.Finasteride metabolism and pharmacogenetics: new approaches to personalized prevention of prostate cancer.Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsEffect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.
P2860
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P2860
CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
@en
type
label
CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
@en
prefLabel
CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
@en
P2093
P2860
P1476
CYP3A4 drug interactions: correlation of 10 in vitro probe substrates.
@en
P2093
Bloomer JC
Houston JB
Kenworthy KE
P2860
P304
P356
10.1046/J.1365-2125.1999.00073.X
P407
P577
1999-11-01T00:00:00Z